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Does Ixekizumab Have Long-term Effects on Improving Psoriatic Arthritis Symptoms?

30. 11. 2020 Source: Biological Treatment

The extension of the SPIRIT-P2 study brought results of ixekizumab in patients with psoriatic arthritis (PsA) after 3 years of use. The data below were presented as a poster presentation at the annual congress of the European League Against Rheumatism (EULAR), which was held virtually in June 2020.

View on the Treatment of Rheumatoid Arthritis with Baricitinib Using the NNT Indicator

Clinical parameters assessed by patients themselves are an important tool in evaluating the effectiveness of new drugs and are particularly significant in the evaluation of treatments for chronic…
30. 11. 2020 Source: Biological Treatment
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Shared Decision-Making on Kidney Function Replacement

Peritoneal dialysis (PD) is not a new development, but its significance is becoming increasingly recognized. Until recently, we may not have fully appreciated its value, but in light of the global…
30. 11. 2020 Source: Chronic Kidney Disease

Options for Modifying and Improving the Efficiency of the HJHS Scoring System

The Hemophilia Joint Health Score (HJHS) is a validated tool for assessing joint health in individuals with hemophilia. Can it be modified to be used more effectively in clinical practice?
30. 11. 2020 Source: Hemophilia with Movement
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Physiotherapy as Part of Comprehensive Care for People with Hemophilia –⁠ Recommendations vs. Reality

It appears that the physiotherapeutic care provided in reality to people with hemophilia does not align with current recommendations, which see it as an integral part of a multidisciplinary approach.…
30. 11. 2020 Source: Hemophilia with Movement
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Use of Brodalumab in the Treatment of Severe Plaque Psoriasis −⁠ Case Report

The case report by MUDr. Jan Šternberský, Ph.D., from the Clinic of Skin and Venereal Diseases, UP Faculty of Medicine and University Hospital Olomouc, demonstrates the excellent effect of brodalumab…
28. 11. 2020 Source: Topical Treatment of Psoriasis
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Hypotension during treatment with sacubitril/valsartan: practical tips for prevention and management

Despite the undeniable benefits of sacubitril/valsartan in terms of morbidity and mortality in patients with chronic heart failure, its administration can be complicated by side effects. The most…
27. 11. 2020 Source: Chronic Heart Failure and Lipidology

Is it possible to predict survival time based on laboratory or radiological findings in patients with IPF?

High-resolution computed tomography (HRCT) imaging of the lungs is a fundamental examination in diagnosing idiopathic pulmonary fibrosis (IPF). According to experts from the Mayo Clinic, it can also…
26. 11. 2020 Source: Pulmonary Fibrosis
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Gliflozins in the Treatment of Type 2 Diabetes According to Current Recommendations SVL

Gliflozins are a relatively new group of antidiabetics with a specific mechanism of action. In addition to glycemic control, they have shown favorable effects on body weight and blood pressure,…
24. 11. 2020 Source: Diabetes
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Combination of Arterial Hypertension and Increased Heart Rate as a Significant Cardiovascular Risk Factor

Heart rate is one of the basic vital signs that should be regularly measured. Sinus tachycardia can be physiological under certain conditions. However, a patient with resting tachycardia should…
23. 11. 2020 Source: Cardiovascular Continuum
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Is Six Months of Adjuvant Targeted Therapy Sufficient for Early Breast Cancer?

The inclusion of adjuvant targeted therapy with chemotherapy for early HER2-positive breast cancer significantly improved patient outcomes. Since 2006, based on data from registration studies, the…
23. 11. 2020 Source: Breast Carcinoma
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Targeted Treatment of Metastatic Breast Cancer in the 2nd Line –⁠ Experiences from Practice

The recommended treatment for metastatic HER2-positive breast cancer in the 1st line involves dual blockade of the HER2 signaling pathway using trastuzumab and pertuzumab in combination with a taxane…
23. 11. 2020 Source: Breast Carcinoma
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Micronutrients in Parenteral Nutrition in Adult Patients –⁠ Current Issues and Consensus

Micronutrients are a key nutritional component, and this is also true for patients whose condition requires the administration of parenteral nutrition. An article published last year in the Journal…
23. 11. 2020 Source: Parenteral Nutrition
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Residual Pulmonary Hypertension After Endarterectomy: How Common Is It?

Pulmonary endarterectomy is the only potentially curative option in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH). What are its outcomes and in what percentage of cases does…
23. 11. 2020 Source: Pulmonary hypertension (CTEPH, PAH)
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Medium to Long-term Results of PFC Sigma Total Knee Arthroplasty

The PFC Sigma knee implant was introduced in 1997. It is the most commonly used system for total knee arthroplasty in England and Wales, accounting for 34.9% of primary implantations in 2006. Studies…
23. 11. 2020 Source: Large Joints
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