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Is It Necessary to Discontinue Dupilumab in Patients with Atopic Dermatitis During the COVID-19 Pandemic?

14. 12. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Italian authors described their experiences with remote treatment of 200 atopic dermatitis (AD) patients using dupilumab during the COVID-19 pandemic outbreak in spring 2020. Observations from clinical practice, published data, and pathophysiological considerations do not suggest an increased risk of SARS-CoV-2 infection in AD patients receiving this biological treatment.

Lékařka_zapis

The safety of dupilumab allows treatment of atopic dermatitis without routine laboratory monitoring

The first comprehensive analysis of laboratory data from 3 clinical trials with dupilumab assessed the incidence of clinically significant changes in hematological or biochemical parameters in…
14. 12. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
výzkum_laboratoř_experiment_medicína_zdravotnictví

Efficacy of Bruton Tyrosine Kinase Inhibitors After Venetoclax Therapy in Patients with CLL

Targeted therapy has changed the treatment approach for chronic lymphocytic leukemia (CLL), showing higher efficacy and safety compared to standard chemoimmunotherapy. Until recently, an important…
11. 12. 2020 Source: Chronic Lymphocytic Leukemia
Léky

When to Switch to Second-Line Treatment for Primary Biliary Cholangitis?

In patients with primary biliary cholangitis (PBC), the response to ursodeoxycholic acid (UDCA) treatment is an important prognostic indicator. To identify patients with an insufficient response to…
10. 12. 2020 Source: Primary Biliary Cholangitis

Frequent Nausea During Chemotherapy Despite Antiemetic Prophylaxis

Current clinical research has focused on vomiting as a primary issue in the occurrence of CINV (chemotherapy-induced nausea and vomiting) and, using recommended antiemetic prophylaxis, this problem…
9. 12. 2020 Source: Antiemetic Therapy
PL_zena_lekar_konzultace

Patient with Diabetes: When to Follow Up and When to Refer to a Specialist?

It is most often the general practitioner (GP) who first diagnoses diabetes. Whether during preventive check-ups, preoperative examinations, or based on the patient's clinical issues. After…
6. 12. 2020 Source: Diabetes
:IMPORT-RN-LOCAL:

Adding Paracetamol to Tramadol to Relieve Early Postoperative Pain After Lumbar Discectomy

A recently published study is likely the first prospective randomized controlled trial comparing the postoperative analgesic efficacy of a tramadol and paracetamol combination versus tramadol alone.…
4. 12. 2020 Source: Pharmacotherapy of Pain
cevni_mozkova_prihoda

Prediction of Ischemic Stroke Risk in Patients with Rheumatoid Arthritis Using a Simplified Score

Ischemic strokes (iCMP) are a common cause of death or significant disability in developed countries. Patients with rheumatoid arthritis (RA) are affected by them even more frequently than the…
3. 12. 2020 Source: Arthritis

The Wound Healing Process Step by Step and What Can Complicate It

Proper care of injuries is a fundamental prerequisite for their successful healing. Knowing the individual phases of healing facilitates treatment and helps prevent the most common complications.
2. 12. 2020 Source: Wound Healing

Hope Awakens with Early Diagnosis of Parkinson's Disease Based on Skin Odor

According to scientists from the United Kingdom, a simple test based on an individual's skin odor could aid the early diagnosis of Parkinson's disease. A study has already been launched to investigate...
2. 12. 2020 Source: Parkinson's Disease

Deep stimulation of the globus pallidus improved clinical symptoms in a patient with refractory parkinsonism and genetic mutation

The authors of the presented work studied the effects of deep brain stimulation (DBS) in a patient with Parkinson's disease with a genetic mutation that manifests in early adulthood.
2. 12. 2020 Source: Parkinson's Disease
Případová studie pacienta

ADCT –⁠ a simple tool for self-diagnosis of patients with severe atopic dermatitis

Atopic dermatitis (AD) is a chronic inflammatory disease not only of childhood. It can negatively affect the quality of life despite being treatable. Control and management of the disease in…
1. 12. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Dupilumab in the Treatment of Adolescent Patients with Severe and Refractory Atopic Dermatitis

An open multicenter study evaluating dupilumab in the treatment of moderate to severe atopic dermatitis in adolescents confirmed its long-term efficacy and safety in this age group. In addition to…
1. 12. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
PL_studie_doktor_ordinace

Noonan's Syndrome –⁠ History and Present

The genetically determined syndrome linking congenital heart defect with a typical facial phenotype is named after Jacqueline Noonan, a pediatric cardiologist who practiced in the second half of the…
30. 11. 2020 Source: Growth Disorders
grafy

Register of Patients Treated with Growth Hormone (REPAR): Data Analysis as a Path to Further Optimization of Care

Treatment with recombinant growth hormone (rhGH) is available in the Czech Republic for all children meeting the indication criteria. A network of 10 centers covers the entire country, and all…
30. 11. 2020 Source: Growth Disorders
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