As of January 1, 2026, a new legal framework has come into effect in the Czech Republic allowing the limited therapeutic use of psilocybin in patients with severe mental health conditions. This represents the first systematic step in translating the results of long-term clinical research on psychedelics into healthcare practice. How does this change clinical practice, and what should physicians know even if they do not provide this therapy themselves?

Czech gastroenterologists have had a professional society bringing them together for eight decades. What can be considered the greatest progress in the field in recent years, which topics were highlighted at the 8th Congress of Czech Gastroenterologists, and how are they coping with current challenges in clinical practice? We discussed this with Assoc. Prof. MUDr. Ilja Tachecí, Ph.D., Head of the 2nd Department of Internal Gastroenterology and President of the Czech Gastroenterological Society of the Czech Medical Association J. E. Purkyně.

In selecting this edition of “bites,” we explored new findings published in leading medical journals —⁠ ranging from the prevention of ventricular arrhythmias and early detection of pancreatic cancer to current results on oral pharmacotherapy for obesity and the treatment of migraine in children and adolescents.

The Precision Psychiatry Roadmap (PPR) is designed as a dynamic process that continuously incorporates new scientific insights into the biological basis of mental disorders into current syndromes defined by clinical symptoms. This represents an important shift —⁠ from traditional symptom-based classification of diseases to precisely targeted, or precision, psychiatry.

Efforts to protect the human body from serious diseases through vaccination date far back into history. Historical sources tell us that the first attempts at immunization already appeared in ancient China. A true breakthrough in this field —⁠ both in terms of the general principle of vaccination and in the fight against the dreaded smallpox —⁠ came at the end of the 18th century, when the English physician Edward Jenner laid the foundations of modern vaccinology. Since then, vaccination has undergone rapid development, and it now appears that we…

Why do some patients with endometriosis have only small lesions yet suffer from unbearable pain, while others with extensive lesions feel almost none? An international team of scientists, in collaboration with the Sbarro Health Research Organization (SHRO), may have found the answer.

Dnešní „jednohubky“ takřka monotematicky věnujeme především kardiovaskulárnímu zdraví a prevenci.

It is not only the home of a legendary scientist said to have made a pact with the devil, but also the site of the Hemodialysis Center of the General University Hospital (VFN). At Prague’s Faust House, representatives of the Department of Nephrology of the First Faculty of Medicine, Charles University, and VFN in Prague commemorated a unique milestone —⁠ the performance of the first hemodialysis not only in former Czechoslovakia, but in the entire socialist bloc.

A study published in Nature Communications presents a system that enables deep brain stimulation without the need for surgery. According to the authors, the device is the first capable of modulating deep brain regions approximately 1,000 times smaller than those accessible with conventional ultrasound devices, and 30 times smaller than those targeted by previous systems designed for deeper brain structures.