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Subclinical Hypothyroidism Associated with the Use of Allopurinol? What the Results of a Large Multicenter Study Suggested

18. 11. 2021 Source: Thyroid Disorders

Allopurinol is a widely used drug for the treatment of hyperuricemia and gout. The retrospective study presented below investigated whether its long-term use is associated with an increased risk of developing subclinical hypothyroidism.

Does the emergence of resistance to cetuximab mean ineffectiveness of all anti-EGFR antibodies?

Colorectal cancer (CRC) cells respond to targeted therapy in different ways. Besides the desired outcome of cell death, CRC cells can adapt and survive through changes in their genome. It is…
12. 11. 2021 Source: Colorectal Cancer
ATB léčba infekcí vyvolaných MDR bakteriemi /Webinář 2.11.2021

VIDEO: Antibiotic Treatment of Infections Caused by MDR Bacteria –⁠ Seminar Recording

Recording of a professional seminar on the topic of infections caused by MDR bacteria, which took place on November 2, 2021, at the Medical House in Prague.
11. 11. 2021 Source: Anti-Infectives
genetika_geny_screening

Genetic Profiling Transforms the Diagnosis and Treatment of Cancer Diseases

Genome sequencing provides doctors with more information about the causes of cancer diseases and changes the ways of treating tumors. Targeted therapy aimed at oncogenic mutations has brought…
11. 11. 2021 Source: Genetic Profile and Treatment of NSCLC
obezita_lide_ulice

Dosing of Enoxaparin in Morbidly Obese Patients

How to optimally dose enoxaparin in morbidly obese patients? This question was addressed by a randomized study, the results of which were published in the journal Annals of Pharmacotherapy.
11. 11. 2021 Source: Thromboprophylaxis
Psoriaza_loket_pacient_lékař

Is long-term treatment with ixekizumab sufficiently safe?

Psoriasis is a chronic inflammatory disease whose manifestations require long-term treatment. A poster presented at last year's European Academy of Dermatology and Venereology (EADV) congress…
8. 11. 2021 Source: Biological Treatment
astma plíce chopn grafika novinka

Do Asthma Bronchiale and COPD Represent a Risk Factor for Severe COVID-19 and Death?

It is well known that patients with bronchial asthma and chronic obstructive pulmonary disease (COPD) have a higher risk of severe course of common viral respiratory diseases. A study by Belgian…
8. 11. 2021 Source: Treatment of Asthma and COPD
Ledviny_ruce

Risk Factors for Renal Cancer Formation After Kidney Transplantation

German authors in the below-cited work identified modifiable risk factors associated with the development of renal cell carcinoma (RCC) de novo in patients after kidney transplantation.
5. 11. 2021 Source: Kidney Carcinoma
Ledvina_karcinom

Kidney Carcinoma –⁠ Key Facts About the Disease With the Highest Incidence Worldwide in the Czech Republic

The incidence of renal carcinoma is increasing every year. About a quarter of the cases are still diagnosed in the metastatic stage, yet early treatment can save lives. Below, we briefly summarize…
5. 11. 2021 Source: Kidney Carcinoma
Mladý mužský pacient na návštěvě ženského lékaře traumatologa

Clinical Characteristics of Trauma Patients Requiring Dosing Adjustments of Enoxaparin in TEN Prevention

Injuries and trauma surgical procedures represent a significant risk factor for the development of thromboembolic disease (TEN). Routine thromboprophylaxis is thus recommended for trauma patients,…
4. 11. 2021 Source: Thromboprophylaxis
krvaceni_tepna_zila_krev

Cost-Effectiveness of Preparations Used to Stop Bleeding in Patients with AHA

Choosing the right preparation to manage acute bleeding in patients with acquired hemophilia A is not always simple. An interesting perspective and recommendations are provided by a model analysis…
1. 11. 2021 Source: Hemophilia

Risk of Developing Inhibitors in People with Milder Forms of Hemophilia

Moderate and mild hemophilia A differ from the severe form not only in clinical course and bleeding risk, but also in the risk of developing neutralizing antibodies (inhibitors).
1. 11. 2021 Source: Hemophilia
NSCLC

Screening using NGS in patients with metastatic NSCLC –⁠ initial results from the ALK-positive cohort

Next-generation sequencing (NGS) allows for obtaining a large amount of information about the tumor genome from a patient's blood sample. Currently, the method is recommended as an alternative in…
1. 11. 2021 Source: Genetic Profile and Treatment of NSCLC
atopic_svědění_adolescent

Efficacy and Safety of Dupilumab in the Treatment of Atopic Dermatitis in Adolescents

In the pediatric population, atopic dermatitis (AD) has a relatively high prevalence, but therapeutic options are often limited. The following article offers a summary of the results from a clinical…
1. 11. 2021 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
:IMPORT-RN:

Quick Relief from Severe AD Symptoms –⁠ Dupilumab for Children Aged 6 Years and Older

Children aged 6-12 with severe atopic dermatitis (AD) have very limited treatment options. The studies presented below demonstrate how effective and safe dupilumab, a monoclonal antibody targeting…
1. 11. 2021 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
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