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How Does Emicizumab Work in Obese Adults with Hemophilia A?

1. 12. 2021 Source: Quality Life Even with Hemophilia

What is the annual bleeding rate and minimum concentration of emicizumab in obese adults with hemophilia A compared to non-obese individuals? Answers were sought by the authors of a pooled post hoc analysis of the HAVEN 1, 3, and 4 studies, the results of which were presented in the poster section of the 2021 ISTH virtual congress. Based on modeling, body weight appears to be an important predictor of emicizumab pharmacokinetics.

klinicka studie

Romiplostim in Routine Clinical Use among Patients with ITP in European Countries −⁠ Fresh Data Analysis

Data from randomized clinical trials have shown that romiplostim is an effective medication for many patients not only with acute or persistent immune thrombocytopenia (ITP) but also for much more…
30. 11. 2021 Source: Immune Thrombocytopenia
Analýza dat

How TPO-RA Drugs Fared in Meta-Analyses of Safety and Efficacy in ITP Patients

Meta-analyses regarding the use of thrombopoietin receptor agonists (TPO-RA) evaluated their efficacy and safety in the treatment of primary immune thrombocytopenia over long-term follow-ups. What…
30. 11. 2021 Source: Immune Thrombocytopenia
Ledviny_ruce

Expanded Hemodialysis and Its Impact on Reducing Hospitalization Rates and Medication Usage

The number of patients with end-stage kidney disease is increasing. New approaches and technological advancements in recent decades have contributed to improving hemodialysis treatment. Does the use…
30. 11. 2021 Source: Chronic Kidney Disease
Karcinom plic

Efficacy of Brigatinib in Patients with Metastatic NSCLC −⁠ Real-World Clinical Data

The journal Lung Cancer published the results of a retrospective analysis of the efficacy of brigatinib in patients with ALK-positive metastatic non-small cell lung cancer (NSCLC) who participated in…
29. 11. 2021 Source: Non-Small Cell Lung Cancer
sepse, krvinky

Monocyte Distribution Width Indicates Sepsis Regardless of Sepsis Etiology

Patients in intensive care units represent a high-risk population for the development of sepsis, which is one of the primary causes of mortality in these settings. The aim of the recently published…
29. 11. 2021 Source: Because
sepse, nebezpečí

News in Laboratory Diagnostics of Early Sepsis −⁠ First Czech Experiences

Sepsis represents one of the most frequent causes of morbidity and mortality in critically ill patients. Laboratory markers play an important role in the diagnosis and prognosis of septic states. The…
29. 11. 2021 Source: Because
analýza krve skumavky

Final Analysis of the STASEY Study: How Did Emicizumab Perform in Prophylaxis of Hemophilia A Patients with FVIII Inhibitors?

The July virtual congress of the International Society on Thrombosis and Haemostasis (ISTH) 2021 offered a range of interesting topics. In its poster section, data from the multicenter single-arm…
29. 11. 2021 Source: Quality Life Even with Hemophilia
fotbal dite zraneni

What does the analysis of the CHESS PAEDs study say about the relationship between physical activity and the frequency of bleeding events in children with hemophilia A?

Currently, there is limited published data addressing the relationship between physical activity and the occurrence of bleeding events in children with hemophilia A. To gain insights into this topic…
27. 11. 2021 Source: Quality Life Even with Hemophilia
Rakovina_pacientka s šátkem_ lékař vysvětluje_ diagnóza

Prognostic Significance of the Location of Colorectal Cancer Metastases

An Austrian study presented at the ESMO 2020 conference analyzed the relationship between the localization of colorectal cancer (CRC) metastases and patient survival, the time of metastasis…
26. 11. 2021 Source: Colorectal Cancer
kardiovaskularny system

Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients with Hypercholesterolemia –⁠ Meta-Analysis of 35 Randomized Controlled Trials

The authors from several American institutions examined the efficacy and safety of two proprotein convertase subtilisin/kexin type 9 (PCSK9i) inhibitors, alirocumab and evolocumab, in their work.…
25. 11. 2021 Source: Hypercholesterolemia
PL_děti_spoluzaci_kluci_skola

HAE Junior Helps Improve the Quality of Life for Pediatric Patients

Living with hereditary angioedema (HAE) brings chronic health issues, long-term psychological stress, and a lifelong threat of death. Initial symptoms of HAE appear during childhood or adolescence.…
24. 11. 2021 Source: Hereditary Angioedema
Antidepresiva_prášky

Early Effect of Once-a-Day Trazodone in the Treatment of Major Depressive Disorder

Most antidepressants have a delayed onset of action, reaching therapeutically effective levels only several weeks after the start of treatment. Trazodone is characterized by a specific mechanism of…
24. 11. 2021 Source: Depression and Anxiety
laborator hemofilia

Gene Therapy for Hemophilia A: What is the Expression of Factor VIII Using the Adeno-Associated Viral Vector SPK-8011?

The goal of gene therapy for hemophilia A is to safely transfer stable and durable expression of coagulation factor VIII (FVIII), which predictably improves the bleeding phenotype at the lowest…
24. 11. 2021 Source: Quality Life Even with Hemophilia
u gynekologa

Von Willebrand Disease in Women

Even in the context of gynecological issues, it is sometimes necessary to consider a hematological etiology of difficulties. The recommendations of the American College of Obstetricians and…
23. 11. 2021 Source: Von Willebrand Disease
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