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Prevalence and Clinical Impact of Overweight and Obesity in the Hemophilia Population

30. 5. 2022 Source: Hemophilia with Movement

Obesity is classified as a lifestyle disease with increasing prevalence and a rising contribution to morbidity and mortality in the general population. The epidemic of overweight and obesity also does not spare individuals with hemophilia. According to epidemiological data, the prevalence of obesity is also increasing in this population, causing a number of complications in many health aspects.

IBD

Tofacitinib Helps Restore Intestinal Epithelial Barrier

The Janus kinase inhibitor (JAKi) tofacitinib was relatively recently approved for the treatment of ulcerative colitis, but its effect on the intestinal epithelium remains a subject of research. The…
30. 5. 2022 Source: Intestinal Inflammations
aktivní psoriatickou artritidou

Safety and Efficacy of Long-term Tofacitinib Therapy in Patients with Active Psoriatic Arthritis –⁠ Interim Results of the OPAL Balance Study

Tofacitinib is a potent selective inhibitor of the Janus kinase (JAK) family indicated for the treatment of active psoriatic arthritis in adult patients. The efficacy and safety of tofacitinib in…
30. 5. 2022 Source: Arthritis
cardiovascular disease arthritis

Cardiovascular Safety of Tofacitinib in Real-World Clinical Practice –⁠ Results of the STAR-RA Study

Recent results from the ORAL Surveillance clinical trial have raised concerns about the cardiovascular adverse effects of tofacitinib in patients with rheumatoid arthritis. A comprehensive analysis…
29. 5. 2022 Source: Arthritis
ULCEROZNI

Maintenance of Remission with Tofacitinib in Patients with UC –⁠ Results of the OCTAVE Open Study

Tofacitinib is indicated for the treatment of ulcerative colitis (UC) in cases where conventional treatment or monoclonal antibodies do not yield sufficient results. Key benefits of this medication…
28. 5. 2022 Source: Intestinal Inflammations
žena_dítě_příroda

Indication of Bilastine in Specific Patient Groups −⁠ Practical Tips for Clinical Practice

Bilastine is a non-sedating H1-antihistamine, which is very well tolerated by patients. It can be indicated in the therapy of allergic diseases in both pediatric and adult populations. What are the…
24. 5. 2022 Source: Allergic Reactions
žena_alergie_rýma_jaro

Bilastine in the treatment of allergic rhinitis –⁠ meta-analysis shows advantage of lower somnolence

A newly published systematic review and meta-analysis evaluate the efficacy and safety of bilastine in the treatment of allergic rhinitis (AR), which includes symptoms of common rhinitis and allergic…
24. 5. 2022 Source: Allergic Reactions
CHOPN_starý muž

Need for Early Intervention in COPD −⁠ A Suitable Time for Mucolytic Treatment

Chronic Obstructive Pulmonary Disease (COPD) ranks third among the leading causes of morbidity and mortality worldwide, with more than 210 million people expected to be affected by 2030. While…
24. 5. 2022 Source: Cough Therapy
Výzkum_grafy

What Did 3 Years of Data from the Czech National COPD Database Reveal?

In December of last year, the Czech multicenter research database on COPD was completed. This was an extensive 5-year project in which researchers included 784 patients with significant chronic…
24. 5. 2022 Source: Cough Therapy
preskribce léků

COPD is Treated Differently Across Europe –⁠ What Could Be the Reasons for This Variability?

As part of this year's Hradec Pneumological Days (HPD 2022), the head of the Pulmonary Clinic at Charles University Faculty of Medicine and University Hospital Hradec Králové, Assoc. Prof. Vladimír…
24. 5. 2022 Source: Cough Therapy
bolest břicha starší muž senior

Prolonged Course of Metastatic Stomach Cancer with Long-term Stabilization –⁠ Case Report

In the following case report, we present the case of a patient with a prolonged oncological disease –⁠ stomach cancer. The patient has been asymptomatic for a long time and in good performance status…
24. 5. 2022 Source: Treatment of Gastrointestinal Carcinomas
statistika grafy výzkum

Focused on MS: Statistics Are Boring, But They Have Valuable Data!

What is the prevalence of multiple sclerosis? Has the proportion of patients treated with highly effective therapy changed? We bring you the latest data from around the world and domestically.
23. 5. 2022 Source: Multiple Sclerosis
mozek mri scan roztroušená skleróza

Epstein-Barr Virus –⁠ Is the Culprit of MS Revealed?

Could the Epstein-Barr virus hold the answer to the etiology of multiple sclerosis? A dataset of over 10 million American recruits offered intriguing insights. You may have encountered the…
23. 5. 2022 Source: Multiple Sclerosis
testování biomarkerů

From Biomarker Testing to NSCLC Treatment Selection

During a satellite symposium at this year's European Lung Cancer Congress (ELCC 2022), Prof. Martin Reck from the Department of Thoracic Oncology at the hospital in Grosshansdorf, Germany, discussed…
23. 5. 2022 Source: Non-Small Cell Lung Cancer
porod_miminko

Is Adding Fibrinogen Concentrate to Transfusion Therapy for Postpartum Hemorrhage an Effective Approach?

Significant postpartum hemorrhage can be managed with fresh frozen plasma transfusion. However, administering larger volumes is associated with several risks. The authors of the Japanese study below…
20. 5. 2022 Source: Life-threatening Bleeding
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