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Autonomic Dysfunction in Patients with Transthyretin Amyloidosis

12. 7. 2022 Source: Amyloidosis

Autonomic nervous system disorders are a common complication of transthyretin amyloidosis. Their frequency, nature, and impact on patients' quality of life were examined in the longitudinal THAOS study.

Overview of Current Treatment Options for MRSA-Induced Pneumonia

Pneumonia caused by methicillin-resistant strains of Staphylococcus aureus (MRSA) remains a disease with high mortality requiring urgent treatment, whether it is a community-acquired or nosocomial…

8. 7. 2022 Source: Anti-Infectives

Postoperative Bleeding in Children with Hypofibrinogenemia Induced by Cardiopulmonary Bypass

Patients undergoing cardiac surgery with the use of cardiopulmonary bypass are at risk of up to a 40% reduction in plasma fibrinogen levels, with subsequent risk of perioperative bleeding. Children…

7. 7. 2022 Source: Life-threatening Bleeding

Experiences with the Treatment of Coagulopathy in Obstetrics –⁠ ROTEM-Guided Algorithm

An observational study from a hospital in Liverpool, UK, was published in the journal Anaesthesia, where they implemented a bleeding management algorithm for obstetric procedures based on rotational…

7. 7. 2022 Source: Life-threatening Bleeding

Incidence and Risk Factors of Community-Acquired Pneumonia in Hematologic Oncologic Patients

Patients with hematologic malignancies are at higher risk of infectious diseases, particularly community-acquired pneumonia, due to immunosuppression. However, recent data providing information on…

5. 7. 2022 Source: Anti-Infectives

Summary of New American Recommendations for Heart Failure Management

This year, the American Heart Association (AHA), the American College of Cardiology (ACC), and the Heart Failure Society of America (HFSA) released joint recommendations for the diagnosis and…

28. 6. 2022 Source: Heart Failure

Full Compensation of Seizures as the Main Goal of Epilepsy Therapy: Will Patients Achieve It More Easily Than 20 Years Ago?

What is the relationship between the quality of life of patients and the degree of seizure compensation? Have the new antiepileptics (ASM) developed over the last decades improved the overall success…

28. 6. 2022 Source: Epilepsy

Safety Profile of Metamizole –⁠ A Systematic Review

Metamizole is a long-established non-steroidal analgesic used for acute and chronic pain management. A systematic review of the literature published in the Journal of Clinical Pharmacy and…

28. 6. 2022 Source: Analgesia

Early and effective treatment of PBC significantly reduced the need for liver transplantation due to this disease

Current European and Czech guidelines include obeticholic acid (OCA) as the only registered option for 2nd line treatment of primary biliary cholangitis (PBC). In the Czech Republic, it is approved…

23. 6. 2022 Source: Primary Biliary Cholangitis

Iron Deficiency and Administration of Ferric Carboxymaltose in Patients with Heart Failure

Iron deficiency is very common in patients with heart failure and is associated with exercise intolerance, reduced quality of life, increased mortality, and higher risk of hospitalization, regardless…

21. 6. 2022 Source: Iron Deficiency and Anemia

Does empagliflozin improve the overall health of patients with heart failure with reduced LVEF?

A recently published secondary analysis of the EMPEROR-Reduced study is based mainly on the results of the KCCQ-23 questionnaire, which assesses the patient's health status from their perspective.…

21. 6. 2022 Source: Heart Failure

Comparison of Dabigatran and Vitamin K Antagonists in Patients with Atrial Fibrillation in Real-World Practice

The final 3-year results of the GLORIA-AF study conducted in real-world practice with patients newly diagnosed with atrial fibrillation show a lower incidence of major bleeding and lower overall…

21. 6. 2022 Source: Anticoagulant Treatment

Low-Molecular-Weight Heparins in Thromboprophylaxis After Major Orthopedic and Traumatological Procedures According to Current Recommendations

Patients after major orthopedic and traumatological procedures are at high risk of thromboembolic disease. This is especially true for people undergoing hip and knee replacement or patients with a proximal...

20. 6. 2022 Source: Thromboprophylaxis

karcinom kolorekta, CRC, Colorectal cancer

Successful Resection of a Rectosigmoid Tumor After Long-term Induction Biochemotherapy –⁠ A Case Report

Neoadjuvant treatment (chemoradiotherapy) for colorectal cancer is regularly used in advanced rectal tumors, with the goal of reducing the tumor size for the surgeon and ensuring the best possible…

20. 6. 2022 Source: Colorectal Cancer

Dupilumab Improves Skin and Systemic Symptoms of Atopic Dermatitis

A clinical study conducted in the USA and Canada demonstrated the efficacy of dupilumab in treating moderate to severe atopic dermatitis, improving both skin symptoms and suppressing systemic…

20. 6. 2022 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

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