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Lung Cancer

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Excellent effect of sotorasib in a higher line of treatment in a patient with NSCLC with G12C mutation of KRAS –⁠ a case study

30. 10. 2024 Source: Lung Cancer

We present a case study of an elderly patient with non-small cell lung cancer (NSCLC) treated with the selective KRASG12C inhibitor sotorasib in the 5th line of oncological treatment, but with a very exceptional effect.

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Inhibition of Mutated KRAS Protein as a New Option for Targeted Treatment of Non-Small Cell Lung Cancer

RAS proteins are molecular switches for several intracellular signaling pathways. Their dysfunction…
9. 11. 2023 Source: Lung Cancer
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Long-term Benefit of Sotorasib for Survival of Patients with Pre-treated Advanced/Metastatic NSCLC with G12C Mutation of KRAS Oncogene

Sotorasib is indicated as monotherapy for advanced non-small-cell lung cancer (NSCLC) with the KRAS…
10. 10. 2023 Source: Lung Cancer
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Change in Mutation Characteristics of NSCLC Detected by Liquid Biopsy –⁠ Case Study

Due to changes in mutations during the progression of metastatic non-small cell lung cancer…
19. 6. 2023 Source: Lung Cancer
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Sotorasib in the Treatment of a Patient with NSCLC and DIC –⁠ A Case Report

Sotorasib is the first clinically used inhibitor of the KRAS oncogene with the G12C mutation.…
24. 5. 2023 Source: Lung Cancer
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Incidence of Brain Metastases and Intracranial Activity of Sotorasib in Patients with NSCLC with G12C Mutation of the KRAS Oncogene

Sotorasib is the first targeted drug approved for the treatment of metastatic non-small cell…
24. 5. 2023 Source: Lung Cancer
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Can We Reach Brain Metastases of Lung Cancer with Anti-EGFR Targeted Therapy?

Information on the penetration of epidermal growth factor receptor tyrosine kinase inhibitors…
11. 1. 2021 Source: Lung Cancer
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Diagnosis, Treatment, and Outcomes Achieved in Patients with Non-Small-Cell Lung Cancer in Central Europe

In June 2020, the journal Radiology and Oncology published the results of an analysis of data…
6. 1. 2021 Source: Lung Cancer
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Treatment with Osimertinib in Patients with NSCLC After Disease Progression on Previous Therapy –⁠ Case Study

We present a case study of a patient with non-small cell lung cancer (NSCLC) with a proven…
16. 6. 2020 Source: Lung Cancer
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Osimertinib in the Treatment of Patients with NSCLC with Secondary EGFR T790M Mutation –⁠ Case Study

Non-small cell lung cancer (NSCLC) is a genetically heterogeneous disease. Individualization…
10. 6. 2020 Source: Lung Cancer
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How to Communicate and Receive an Oncological Diagnosis

Communicating the truth about a patient's health condition does not have a very long tradition...
4. 6. 2020 Source: Lung Cancer
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Patient Evaluation of Durvalumab Treatment Results

The interim analysis results of the PACIFIC study, which monitored the efficacy of durvalumab…
31. 3. 2020 Source: Lung Cancer
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