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Rurioctocog alfa pegol in previously treated patients with severe hemophilia A: What findings did the long-term continuation study bring?

2. 11. 2020 Source: Hemophilia

Rurioctocog alfa pegol (Adynovi) is a recombinant coagulation factor VIII modified by pegylation, which results in an approximately 1.5× prolonged biological half-life compared to standard half-life FVIII. Previous studies have already confirmed the favorable profile of this drug in prophylaxis for patients with hemophilia A. Recently published results of a prospective multicenter continuation study in children and adult patients under 75 years old with severe hemophilia A (baseline FVIII level < 1%) were based on an observation period…

medicina_budoucnost_krev_srazlivost_krevni_desticky

Position of aPCC in the Treatment of Hemophilia A Complicated by the Development of Inhibitors

Activated prothrombin complex concentrates (aPCC) are essential drugs that not only allow the control of bleeding in patients with congenital hemophilia A and inhibitors but also help to prevent such…
2. 11. 2020 Source: Hemophilia
štítná žláza grafika

Anxiety Disorders and Autoimmune Thyroiditis –⁠ A Connection Rather Than Coincidence?

Anxiolytics commonly target the central nervous system. Newly published research by Ukrainian authors offers a different perspective –⁠ according to their findings, anxiety may be related to thyroid…
29. 10. 2020 Source: Depression and Anxiety
Lymfom_analýza_krve

Targeted Treatment and Quality of Life in Patients with Follicular Lymphoma

The GALLIUM clinical trial evaluated chemotherapy in combination with targeted treatment using rituximab or obinutuzumab in previously untreated patients with advanced follicular lymphoma (FL). A…
27. 10. 2020 Source: Non-Hodgkin Lymphomas and CLL
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Sport Therapy as Part of Hemophilia Management

A study by authors from the University of Wuppertal in Germany specifically examined the impact of a half-year programmed sport therapy on the subjective physical performance and quality of life of…
27. 10. 2020 Source: Hemophilia with Movement
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EHL preparations have the potential to change the quality of life for people with hemophilia

Within the therapeutic modalities for hemophilia, the current era offers a number of preparations. Newer extended half-life (EHL) replacement therapies can provide hemophiliacs with better protection…
27. 10. 2020 Source: Hemophilia with Movement
COVID_19

Idiopathic Thrombocytopenic Purpura with SARS-CoV-2 Infection

To date, 45 cases of idiopathic (autoimmune) thrombocytopenic purpura (ITP) in individuals with confirmed SARS-CoV-2 infection have been published in the literature. In September 2020, a review…
27. 10. 2020 Source: Immune Thrombocytopenia
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Current Data on the Safety Profile of Baricitinib in the Treatment of Rheumatoid Arthritis

Baricitinib was approved for the treatment of rheumatoid arthritis (RA) in 2017, making it essential and relevant to monitor its safety profile in clinical practice. The analysis of data collected…
26. 10. 2020 Source: Biological Treatment
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Efficacy of Baricitinib in Long-term Therapy of Rheumatoid Arthritis

Baricitinib selectively and reversibly inhibits Janus kinases JAK1 and JAK2 and is used in the treatment of adults with active rheumatoid arthritis (RA). Its safety during long-term administration…
26. 10. 2020 Source: Biological Treatment

Ixekizumab is a Safe Option for Long-Term Treatment of Inflammatory Diseases

Psoriasis, psoriatic arthritis (PsA), and axial spondyloarthritis (SpA) are chronic inflammatory diseases that often require long-term treatment. The current pharmacotherapy of these diseases…
26. 10. 2020 Source: Biological Treatment
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Possibilities of Using Metamizole in the Treatment of Acute Primary Headaches

The aim of the review article by Brazilian authors was to summarize the efficacy and safety of metamizole in the treatment of acute primary headaches, such as migraine, episodic tension-type headache…
26. 10. 2020 Source: Analgesia
Tým lékařů

Chemoimmunotherapy in the Treatment of Breast Cancer −⁠ Final Results of the IMpassion130 Study

According to international recommendations, treatment with the immune checkpoint inhibitor atezolizumab in combination with the cytostatic nab-paclitaxel is used for patients with locally advanced or…
25. 10. 2020 Source: Breast Carcinoma
Onkologická pozitivní pacientka

Fixed Combination of Trastuzumab and Pertuzumab for Subcutaneous Administration in Patients with Early Breast Cancer

At a symposium focused on breast cancer, held in December 2019 in San Antonio, Texas, preliminary results of the FeDeriCa clinical study were presented –⁠ comparing the pharmacokinetics, efficacy, and…
25. 10. 2020 Source: Breast Carcinoma
Seznam vědců_medical_study

Dysregulation of microRNA Expression After Treatment with Anti-EGFR Antibodies

A team of researchers from Plzeň decided to verify whether treatment with anti-EGFR antibodies changes the expression of selected microRNAs in patients with metastatic colorectal carcinoma (mCRC).…
22. 10. 2020 Source: Colorectal Cancer
Results

Panitumumab in 1st Line in Older Patients –⁠ Results of the PANDA Study

The phase II PANDA study evaluated the regimens FOLFOX + panitumumab versus 5-FU + panitumumab in the 1st line treatment of patients with wt-RAS/BRAF metastatic colorectal cancer (mCRC).
22. 10. 2020 Source: Colorectal Cancer
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