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Options for Reducing or Discontinuing TPO-RA Therapy in ITP Patients −⁠ Expert Consensus

20. 5. 2021 Source: Immune Thrombocytopenia

There are currently no clear recommendations regarding dose reduction or discontinuation of thrombopoietin receptor agonists (TPO-RA) in patients with immune thrombocytopenia (ITP). A consensus by British authors offers insights into current clinical practice and the related issues.

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Safety and Effectiveness of Lurasidone in Adolescents with Schizophrenia

An open-label extension of a placebo-controlled study involving 271 patients aged 13–17 years with schizophrenia showed minimal impact on body weight, lipid levels, prolactin, and blood glucose…
18. 5. 2021 Source: Modern Treatment of Schizophrenia
Schizofrenie_ataka_žena

Adverse effects of antipsychotics in the treatment of schizophrenia negatively affect cognitive functions

Schizophrenia is a severe psychiatric disorder characterized by a wide range of symptoms, with cognitive dysfunctions being one of its domains. Antipsychotics (APs) are used for treatment, but their…
18. 5. 2021 Source: Modern Treatment of Schizophrenia
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Systemic Manifestations of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by remodeling of the pulmonary vessels, leading to the development of right-sided heart failure. Aside from the…
16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
Bezpečnost_léky_farmakovigilance

Safety of Riociguat in the Treatment of Thromboembolic Pulmonary Hypertension in Common Practice

In March 2021, the final safety results of riociguat in the treatment of thromboembolic pulmonary arterial hypertension in real-world practice were published from the international EXPERT registry,…
16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
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Alpha-1-Antitrypsin Deficiency and Its Association with Atopy in Asthmatics

Literature mentions the coincidence of asthma and alpha-1-antitrypsin deficiency, which is caused by a mutation in the SERPINA1 gene. The aim of the study presented below was to determine whether the…
14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin
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Antiviral and Anti-inflammatory Effects of Alpha-1-Antitrypsin in the Treatment of COVID-19

Human alpha-1-antitrypsin (AAT) is a circulating blood glycoprotein that has been used for decades in the treatment of patients with AAT deficiency, lung damage, and emphysema, helping to prevent…
14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin
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To what extent can the actual level of ALP, ALT, or bilirubin differ from the measured value?

A physician who bases clinical decisions on laboratory-determined values of biological parameters or their changes should always consider the possible measurement deviation, which for alkaline…
14. 5. 2021 Source: Primary Biliary Cholangitis
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Treatment of Motor Symptoms of Parkinson's Disease

Parkinson's disease (PD) is one of the few neurodegenerative disorders for which effective symptomatic treatment is available. Unfortunately, causal or even neuroprotective therapy with proven…
12. 5. 2021 Source: Parkinson's Disease
medicína žena břicho bolest žaludek stomie

Liposomal Pegylated Irinotecan in the Treatment of Pancreatic Tumors

Combined treatment with liposomal pegylated irinotecan, 5-fluorouracil (5-FU), and leucovorin (LV) significantly improves overall survival in patients with metastatic ductal carcinoma of the…
11. 5. 2021 Source: Treatment of Gastrointestinal Carcinomas
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New Treatment Option for Metastatic Pancreatic Cancer –⁠ Pegylated Liposomal Irinotecan

The 2019 review article is dedicated to the use of nanoliposomal irinotecan, its toxicity, and its potential use in the treatment sequence of metastatic pancreatic ductal adenocarcinoma.
11. 5. 2021 Source: Treatment of Gastrointestinal Carcinomas
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What FVIII Levels Are Ideal for Preventing Bleeding in Hemophilia A?

Recent studies indicate that target trough levels of factor 1–3% during prophylactic treatment are insufficient to fully prevent clinical and subclinical bleeding. With a sustained FVIII level > 15%,...
10. 5. 2021 Source: Hemophilia
léky_lékař

Can Co-administration of Dabigatran with Antiretroviral Drugs Be Effective and Safe?

In 2019, the first results regarding the concurrent use of antiretroviral drugs and oral anticoagulants were published. This involved 14 patients with atrial fibrillation and HIV infection, in whom…
6. 5. 2021 Source: Anticoagulant Treatment
Lékař v chirurgickém oděvu drží endoskop v ruce. Pacient a sestra v pozadí.

The Future and Prospects of Type 2 Diabetes Therapy: Can We Fully Cure It with Endoscopy or Genetics?

Diabetes mellitus (DM) cannot be cured, but it can be successfully treated... Will we rewrite this textbook fact passed down for years in the future? Will we be able to completely cure type 2…
6. 5. 2021 Source: Modern Treatment of Diabetes
Tým lékařů

Thyroid Function During COVID-19 Illness and After Recovery

Acute infection with the SARS-CoV-2 coronavirus has varying impacts on different organ systems of the human body. Until now, it has not been certain how precisely it affects the endocrine system,…
6. 5. 2021 Source: Thyroid Disorders
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