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Intracranial Activity of Lorlatinib in Patients with Metastatic ALK-Positive NSCLC

23. 7. 2021 Source: Genetic Profile and Treatment of NSCLC

Lorlatinib is a potent third-generation anaplastic lymphoma kinase (ALK) inhibitor with significant antitumor activity against non-small cell lung cancer (NSCLC). According to the results of an international clinical study published in the Annals of Oncology, it shows very good efficacy in treating intracranial metastases in patients who experienced disease progression during therapy with second-generation ALK inhibitors.

Experiences with treating PBC with obeticholic acid in Brno's CKTCH

MUDr. Libuše Husová, Ph.D., shared the current insights from the therapy of patients with primary biliary cholangitis (PBC) using obeticholic acid (OCA) gained at the Center for Cardiovascular and Transplantation...

22. 7. 2021 Source: Primary Biliary Cholangitis

Dabigatran Etexilate in the Treatment of Acute Thromboembolic Disease in Children

Until now, standard anticoagulants such as low-molecular-weight heparin or unfractionated heparin and others have been used in pediatric patients for the treatment of thromboembolism. The study…

22. 7. 2021 Source: Anticoagulant Treatment

When to Stop Dabigatran Anticoagulation Treatment Before Catheter Ablation in Patients with Atrial Fibrillation?

Catheter ablation is now a standard method of treating atrial fibrillation. Its most common complications are bleeding and thromboembolism. The aim of the analysis of 2 clinical studies presented…

22. 7. 2021 Source: Anticoagulant Treatment

Dust Mite Allergies: Common Does Not Mean Trivial

Dust mite allergies are almost ubiquitous problems that we perceive as part of the 'broader norm.' However, patients do not see it this way, so we should not lose sight of it.

22. 7. 2021 Source: Dust Mite Allergy

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OCA in Second-Line Treatment of PBC: Analysis Results and Real-World Data

Ursodeoxycholic acid (UDCA) is the cornerstone treatment for PBC according to the guidelines of the European Association for the Study of the Liver (EASL). However, many patients (25–50%) do not achieve...

21. 7. 2021 Source: Primary Biliary Cholangitis

Bilastine as a reliable helper in the treatment of allergic rhinoconjunctivitis and urticaria even in younger children

Until recently, bilastine was indicated for the treatment of allergic rhinoconjunctivitis and urticaria only in patients over 12 years of age. However, current findings from valid studies demonstrate…

21. 7. 2021 Source: Allergic Reactions

Key for Patients with PBC are Timely Diagnosis and Assessment of Therapy Effectiveness

Primary biliary cholangitis (PBC) cannot be cured. It progresses slowly and over several decades leads to liver cirrhosis with all its potential consequences, including possible transplantation and the...

19. 7. 2021 Source: Primary Biliary Cholangitis

Von Willebrand Disease as a Cause of Abnormal Uterine Bleeding

Abnormal uterine bleeding constitutes a large portion of complaints among women of reproductive age. This type of bleeding is typical for von Willebrand disease (vWD), but also for other types of…

16. 7. 2021 Source: Von Willebrand Disease

Negative Symptoms of Schizophrenia and Their Assessment

Schizophrenia is a serious psychiatric disorder with a prevalence of up to 1%. It can manifest with both negative and positive symptoms. We briefly summarize the clinical assessment and rating scales…

14. 7. 2021 Source: Schizophrenia and Antipsychotics

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Dabigatran vs. Warfarin: What and Why Do Patients Prefer?

The key to adherence to long-term anticoagulant therapy is primarily the satisfaction of patients with the set therapy. The RE-SONANCE study published in April 2021 compared patient satisfaction with…

1. 7. 2021 Source: Anticoagulant Treatment

New Recommendations for Intravenous Thrombolysis in the Treatment of Acute Ischemic Stroke –⁠ ESO Guidelines 2021

Intravenous thrombolysis is the only approved systemic reperfusion therapy for patients with acute ischemic stroke (AIS). The most commonly used thrombolytic is alteplase. Earlier this year, the…

1. 7. 2021 Source: Anticoagulant Treatment

Alpha-1 Antitrypsin Deficiency and Lung Disease in Patients with Primary Immunodeficiencies

Alpha-1 antitrypsin deficiency (AATD) plays a significant role in the pathogenesis of pulmonary emphysema, chronic obstructive pulmonary disease (COPD), and bronchiectasis. However, its deficiency…

1. 7. 2021 Source: Deficiency of Alpha-1-Antitrypsin

Can identifying alpha-1 antitrypsin deficiency before liver transplantation extend survival?

Alpha-1 antitrypsin deficiency (AATD) can manifest (among other things) as liver cirrhosis. The study presented below examined the survival of patients diagnosed with AATD before and after liver…

1. 7. 2021 Source: Deficiency of Alpha-1-Antitrypsin

Expression of PD-L1 as a Predictive Biomarker for Therapy Selection in mRCC

A newly published systematic review and meta-analysis of studies involving patients with metastatic renal cell carcinoma (mRCC) evaluates the predictive significance of PD-L1 expression in the…

1. 7. 2021 Source: Kidney Carcinoma

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