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Diagnosis of AAT Deficiency According to Italian Recommendations and a Clear Algorithm for Practice

1. 11. 2022 Source: Deficiency of Alpha-1-Antitrypsin

Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that primarily affects the lungs and liver. It is considered a rare disease, but it is also significantly underdiagnosed. Given the availability of specific treatment, which involves the administration of purified alpha-1 antitrypsin (AAT) derived from human plasma in patients with COPD due to AATD, identifying these patients is crucial. We summarize the recently issued Italian recommendations for the diagnosis of AATD and place them in the context of Czech standards.

Does adding statins to DOACs reduce the risk of major bleeding in patients with non-valvular atrial fibrillation?

A large retrospective study, the results of which were recently published, investigated to what extent the concurrent administration of statins is associated with a lower risk of major bleeding,…

1. 11. 2022 Source: Anticoagulant Treatment

ESC 2022: Evidence of SGLT2i Effectiveness in HFrEF Treatment is Growing: How to Integrate Them into Routine Practice?

Although the need for pharmacotherapeutic options for patients with heart failure with reduced left ventricular ejection fraction (HFrEF) is essential, challenges in implementing this medication…

1. 11. 2022 Source: Heart Failure

What Can We Expect from Sorafenib in the Treatment of Liver Cancer Affected by Nonalcoholic Fatty Liver Disease?

Ubiquitous and increasingly common obesity is a risk factor for many cancers. Over the past 20 years, studies have linked obesity to higher incidences of breast and colorectal cancers, as well as…

31. 10. 2022 Source: Oncological Treatment

Alopecia Areata –⁠ Autoimmune Inflammatory Disease and a New Targeted Treatment Option

Alopecia areata (AA) is one of the non-scarring focal alopecias. It is an autoimmune disease of the hair follicle, the etiopathogenesis of which is not entirely understood. At the hair root, a…

31. 10. 2022 Source: Biological Treatment

Contact Dermatitis in Patients with Venous Ulcers –⁠ and How to Prevent It?

The prevalence of chronic wounds increases with the rising average age, and for example, venous ulcers affect up to 2% of the global population. Materials used for wound coverage, however, present a…

31. 10. 2022 Source: Wound Healing

Prim. Václava Adámková: People mistakenly believe that there are enough antibiotics and that they will always handle infections

According to the World Health Organization (WHO), by 2050, infections untreatable with antibiotics could become the leading cause of death, surpassing cardiovascular and oncological diseases. Rising…

26. 10. 2022 Source: Anti-Infectives

Options for Tapering TPO-RA in ITP Patients: Practical Experience and Expert Consensus

A recently published British study aims to provide recommendations on tapering TPO-RA in patients with immune thrombocytopenia (ITP) based on existing evidence, survey results of clinical practice…

25. 10. 2022 Source: Immune Thrombocytopenia

Effect of Romiplostim in Refractory ITP with Possibility of Maintaining Response Without Treatment –⁠ Case Report

This case report from the United States features an ideal therapeutic response to romiplostim in a patient with refractory immune thrombocytopenia (ITP). After several years of successful therapy,…

25. 10. 2022 Source: Immune Thrombocytopenia

Newer Beta Blockers Offered for Use in Atherosclerosis Prevention

An article highlighting recent scientific findings on the beneficial effects of beta-blockers (BB) directly on the arterial wall and the potential benefit for the prevention of atherosclerotic…

25. 10. 2022 Source: Cardiovascular Continuum

Will up-titration or combination with bisoprolol help to better control hypertension in amlodipine users?

Will patients with hypertension who do not achieve control of this condition with amlodipine at a dose of 5 mg benefit more from up-titration or combining it with bisoprolol? The answer to this…

25. 10. 2022 Source: Cardiovascular Continuum

EMPATHY Questionnaire as a Tool for Better Personalization of Levothyroxine Doses in Patients with Primary Hypothyroidism?

The therapy for hypothyroidism consists of substitution with levothyroxine (L-T4). Failure to achieve the target thyrotropin hormone (TSH) level can be due to non-compliance (in 60% of cases) or…

25. 10. 2022 Source: Thyroid Disorders

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