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Fresh data from real clinical practice on targeted treatment of RA with etanercept: Should therapy be changed after 12 weeks due to insufficient response?

24. 11. 2022 Source: Arthritis

A recently published German study investigated, among other things, what percentage of patients with rheumatoid arthritis (RA) achieve remission or low disease activity after a certain period of etanercept treatment in real clinical practice.

Current NCCN Recommendations for CLL/SLL Diagnosis –⁠ Version 1.2023

In August 2022, the latest guidelines from the National Comprehensive Cancer Network (NCCN) concerning chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) were published. Here we…

23. 11. 2022 Source: Chronic Lymphocytic Leukemia

Impact of Initial RAAS Inhibitor on Hospitalization Risk in HFrEF Patients

Inhibition of the renin-angiotensin-aldosterone system (RAAS) is considered a key step in the treatment of heart failure with reduced ejection fraction (HFrEF). The preferred medication currently is…

23. 11. 2022 Source: Chronic Heart Failure and Lipidology

Efficacy and Safety of Levodopa/Entacapone/Carbidopa Combination in the Treatment of Advanced Parkinson's Disease –⁠ Prospective ELEGANCE Study

Therapy for advanced Parkinson's disease (PD) with a triple combination of levodopa/entacapone/carbidopa in the form of intestinal gel (LECIG) was first introduced to the Swedish market in 2018. The…

22. 11. 2022 Source: Parkinson's Disease

First Experiences with the Combination of Levodopa/Entacapone/Carbidopa in Intestinal Gel from the Perspective of Patients with Parkinson's Disease

The work presented at the 8th Congress of the European Academy of Neurology (EAN) in Vienna in June 2022 summarizes the first experiences with the use of intestinal gel combining the active…

22. 11. 2022 Source: Parkinson's Disease

The role of the physiotherapist in hemophilia care is expanding and irreplaceable −⁠ what it entails and how it changes with treatment advances?

In the team cooperation in caring for patients with hemophilia, the physiotherapist plays a very important role, which is expanding with today's comprehensive approach to treating this condition. The…

21. 11. 2022 Source: Hemophilia with Movement

Impact of the combination of bevacizumab with erlotinib in patients with NSCLC and EGFR mutation on overall survival and time to disease progression

Dual inhibition of the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) can delay resistance to chemotherapy in patients with advanced-stage non-small cell lung…

21. 11. 2022 Source: Oncological Treatment

When the Cause of Hematomas in Anticoagulated Patients is Not Anticoagulants –⁠ Case Report

Not every bleeding during anticoagulation, especially if within the therapeutic range, can be attributed to this treatment. Particularly in older individuals and the presence of typical extensive…

18. 11. 2022 Source: Acquired Hemophilia

Rebound effect after denosumab discontinuation in a patient with lung cancer

The case study of a patient with metastatic lung cancer describes the emergence of vertebral fractures following the discontinuation of denosumab. This antiresorptive treatment was halted…

16. 11. 2022 Source: Prevention of Bone Events

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Prevention of Symptomatic Skeletal Events in Postmenopausal Women with Advanced ER-Positive Breast Cancer

Advanced breast cancer with the presence of estrogen receptors is one of the most common cancers worldwide. Hormonal treatment for this malignancy is highly effective, but it is accompanied by risks…

16. 11. 2022 Source: Prevention of Bone Events

Current Approaches to COPD Therapy According to GOLD Recommendations and in the Conditions of Czech Practice

Chronic Obstructive Pulmonary Disease (COPD) represents a significant global cause of morbidity and mortality with a high prevalence that is expected to increase significantly in the coming years.…

15. 11. 2022 Source: Treatment of Asthma and COPD

Impact of Rehabilitation on the Health of Patients with COPD

According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), pulmonary rehabilitation is one of the most effective therapeutic interventions for reducing dyspnea, improving…

15. 11. 2022 Source: Treatment of Asthma and COPD

ESC 2022: Heart Failure with Preserved Ejection Fraction as an Underdiagnosed Problem: How to Increase Its Detection in Everyday Practice?

During this year's European Society of Cardiology Congress (ESC 2022), alarming information was shared, indicating that heart failure with preserved ejection fraction of the left ventricle (HFpEF) is…

14. 11. 2022 Source: Heart Failure

Estimated Worldwide Prevalence of Population with AAT Deficiency with MZ Alleles

Alpha-1-antitrypsin deficiency (AATD) with the MZ genotype was until recently associated with negligible or low risk for lung and liver tissue damage. However, growing evidence suggests that carriers…

14. 11. 2022 Source: Deficiency of Alpha-1-Antitrypsin

Repeated Episodes of Respiratory Failure Due to Undiagnosed AAT Deficiency –⁠ Case Report

The case report from authors in Naples shows that alpha-1-antitrypsin deficiency (AATD) should be considered when respiratory symptoms occur at any age. It also illustrates the diagnostic procedure…

14. 11. 2022 Source: Deficiency of Alpha-1-Antitrypsin

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