News
CYP Enzyme? Cytochrome P450 2D6 and Drug Metabolism
The CYP2D6 isoenzyme of cytochrome P450 participates in the metabolism of approximately 20% of commonly used drugs. Genetic variants of this enzyme are very common, leading to significant inter-individual variability in drug metabolism rates. Let’s take a closer look at one of the reasons why the same drug may work very well in one patient, not at all in another, and may cause serious side effects in a third.
Association of M2 Haplotype of the Annexin A5 Gene with Recurrent Reproductive Losses
Annexin A5 (ANXA5) is a placental anticoagulant protein that ensures adequate blood supply to the…
Etiology of Recurrent Reproductive Losses – Focus on Genetics
Repeated pregnancy losses pose a significant threat to a woman's physical and mental health. The…
Li-Fraumeni Syndrome – Indication for Testing and Recommended Surveillance
A germline mutation of the TP53 gene, which causes Li-Fraumeni syndrome, results in a congenital predisposition...
Water Microjet as a Gentler Method of Debridement
Debridement is an integral part of chronic wound treatment. Currently, the most common method is…
Dravet Syndrome – Get to Know It
Dravet syndrome is a severe myoclonic epilepsy occurring in early childhood. It is classified as a…
When and why to consider the diagnosis of myasthenia gravis in neurological practice, and what treatment options do we currently have?
Myasthenia gravis (MG) is a clinically heterogeneous disease characterized by fluctuating muscle…
Sjögren's Syndrome as a Cause of Dry Eye Syndrome
Primary Sjögren's syndrome represents a complex autoimmune disease primarily affecting glands with…
Infographic and Commentary from Practice: Reasons and Pathways for Patients to Biological Treatment of Asthma
For asthma patients with the most severe forms of the disease to access targeted biological…