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oncology

Osteonecrosis of the Jaw Associated with Antiresorptive Pharmacotherapy in Oncological Patients

8. 6. 2023 Source: Prevention of Bone Events

Antiresorptive pharmacotherapy in the form of bisphosphonates and denosumab is associated, according to current knowledge, with the risk of jaw osteonecrosis, especially following dental procedures such as tooth extractions. The aim of the newly published systematic review was therefore to evaluate the incidence of this complication following dental extractions in connection with the administration of antiresorptive medication and to identify risk factors for jaw osteonecrosis in oncological patients.

lekar_pacient

Prediction of Hypocalcemia Risk in Patients Treated with Denosumab and Active Form of Vitamin D

According to new work by Japanese authors, it appears that the risk factors for the development of hypocalcemia in patients treated with denosumab and calcitriol (the active form of vitamin D) are…
8. 6. 2023 Source: Prevention of Bone Events
metaanalýza

Meta-analysis of Efficacy and Safety of Third-Generation Antiseizure Medications in Adjunctive Treatment of Focal Seizures in Adults with Epilepsy

Epilepsy treatment is primarily symptomatic, aimed at reducing seizure frequency. However, more than 50% of patients do not achieve seizure freedom with monotherapy. Below we summarize the results of…
8. 6. 2023 Source: Epilepsy
Epilepsie léky

How Does Cenobamate Compare with Third-Generation Anti-Seizure Medications in Terms of Cost-Effectiveness?

The main goal of epilepsy treatment is to achieve seizure freedom without unacceptable side effects of therapy. Despite the benefits of the latest generation of anti-seizure medications (ASMs),…
8. 6. 2023 Source: Epilepsy
lung diseases rheumatism

Comparison of the Risk of Interstitial Lung Disease in Patients with RA with Biological and Targeted Disease-Modifying Antirheumatic Therapy

The authors of a newly published study sought to answer whether the risk of developing interstitial lung disease in patients with rheumatoid arthritis (RA) is affected by the administration of…
8. 6. 2023 Source: Arthritis
leukémie stará žena

Effect of Azacitidine in the Treatment of Acute Myeloid Leukemia on Long-Term Patient Survival

The work cited below presents freshly updated results from the Quazar AML-001 study evaluating azacitidine (AZA) in the treatment of acute myeloid leukemia (AML), now with a median follow-up period…
6. 6. 2023 Source: Acute Myeloid Leukemia
chemoterapie_žena

Oral Azacitidine Prolongs Survival of AML Patients Regardless of Measurable Residual Disease

Intensive chemotherapy for patients newly diagnosed with acute myeloid leukemia (AML) often achieves high remission rates, although these remissions are often only temporary. Consolidation therapy…
6. 6. 2023 Source: Acute Myeloid Leukemia
vakcinace

Vaccination and ALEmtuzumab: ALE when?

When, why and against what should patients with multiple sclerosis treated with alemtuzumab be vaccinated? And is vaccination effective in this population?
5. 6. 2023 Source: Multiple Sclerosis
cestovaniRS

Traveling with MS –⁠ Is Vaccination a Limitation?

What about the need for vaccination when traveling abroad? Which vaccines should you be cautious about? And how to time vaccination concerning disease activity and the individual medications used in…
5. 6. 2023 Source: Multiple Sclerosis
Keto dieta

Can Ketogenic Diet or Intermittent Fasting Help Patients with DM2 in Controlling Weight and Glycemia?

The foundation of managing type 2 diabetes mellitus (DM2) typically involves lifestyle adjustments, including dietary changes. Can intermittent fasting (IF) or the ketogenic diet (KD), popular…
30. 5. 2023 Source: Modern Treatment of Diabetes
Noha fixace

New Type of Fixation Allows Regular Limb Hygiene and Stay in Water

Conservative therapy for injuries and non-traumatic diseases of the musculoskeletal system is a daily reality in surgical and orthopedic clinics. An important part of treatment is limb fixation, most…
26. 5. 2023 Source: medScope.pro
antikoagulační léčba pohled na tělo a srdce

Predictors and Rate of Anticoagulant Therapy Discontinuation in Patients with Atrial Fibrillation

With the worldwide increase in the prevalence of atrial fibrillation (AF), the use of anticoagulants (warfarin, DOACs –⁠ direct oral anticoagulants) to reduce the risk of ischemic stroke (iCMP) is…
25. 5. 2023 Source: Anticoagulant Treatment
Žena si měří tlak a sahá si na hruď

Association Between Sartan Therapy and Lower Incidence of Epilepsy in Hypertensive Patients?

Arterial hypertension (AH) is one of the non-cerebral comorbidities of epilepsy, with the renin-angiotensin system possibly being the central mediator of the connection between these diseases. The…
25. 5. 2023 Source: Sartans in the Treatment of Hypertension
prostredi_z_nemocnice

RETRO-TAS Study –⁠ Trifluridine/Tipiracil in Pretreated mCRC in Real-World Practice

How does trifluridine/tipiracil (FTD/TPI), which demonstrated efficacy in clinical trials in chemotherapy-refractory metastatic colorectal cancer (mCRC), fare in real-world practice? This was…
25. 5. 2023 Source: Treatment of Gastrointestinal Carcinomas
screening

Study TACTIC –⁠ Efficacy and Safety of Trifluridine/Tipiracil in Pre-treated mCRC Patients in Real-world Practice

In the pivotal phase III RECOURSE randomized placebo-controlled study, therapy with trifluridine/tipiracil (FTD/TPI) was associated with improved overall survival and progression-free survival in…
25. 5. 2023 Source: Treatment of Gastrointestinal Carcinomas
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