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karcinom

Pegylated Liposomal Irinotecan + 5-FU/LV in the Treatment of mPDAC in Czech Clinical Practice –⁠ Results from the VILP Registry

25. 3. 2024 Source: Treatment of Gastrointestinal Carcinomas

At last year's annual congress of the European Society for Medical Oncology (ESMO) and this year's 15th PragueONCO, results from the Czech VILP registry were presented. This registry collected data on patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with pegylated liposomal irinotecan (nal-IRI) in combination with 5-fluorouracil (5-FU) and leucovorin (LV). The efficacy and safety of nal-IRI + 5-FU/LV in patients with mPDAC after failure or intolerance to gemcitabine-based chemotherapy, as found in the randomized…

psoriaza

Bimekizumab in 3rd Line Biological Treatment After Risankizumab Failure –⁠ Case Study

The possibilities of biological therapy for severe forms of psoriasis are very broad today. Achieving remission or reducing disease activity by 90-100% from the baseline state (PASI 90-100) is highly...
22. 3. 2024 Source: Psoriasis
umělá inteligence vývoj léčiv

How Does Artificial Intelligence Help in Drug Development?

In recent years, technologies leveraging artificial intelligence have transitioned from potentially interesting novelties to real clinical development programs. What can artificial intelligence offer…
20. 3. 2024 Source:
Pacient schizofrenie_léky

Improvement in social functioning of patients with schizophrenia during treatment with lurasidone

A beneficial impact on social functioning is an important outcome of schizophrenia treatment. A recently published Japanese study is the first to demonstrate the efficacy of lurasidone compared to…
19. 3. 2024 Source: Modern Treatment of Schizophrenia
kardio srdce

What to add to amlodipine when it alone is not enough for hypertension?

Treating hypertension is a daily task for not only general practitioners and cardiologists. Polish doctors evaluated the effect of adding bisoprolol on the blood pressure of patients with…
18. 3. 2024 Source: Cardiovascular Continuum
diabetes zena měrení

Effect of Extended-Release Metformin on Cognitive Functions in Older Frail Women with Diabetes and Hypertension

Women have a higher risk of geriatric frailty regardless of age and menopausal status. This risk further increases with the presence of diabetes and hypertension, which also elevate the risk of…
14. 3. 2024 Source: Cardiovascular Risks
srdce

ACC 2023 Expert Consensus: How to Optimize Diagnosis and Treatment of Heart Failure with Preserved EF LK

Heart failure (HF) remains a significant cause of morbidity and mortality, with the incidence and prevalence of HF with preserved left ventricular ejection fraction (HFpEF) rising. The following…
14. 3. 2024 Source: Heart Failure
obezita_váha

Causes, Consequences, and Solutions to Weight Gain in Schizophrenia Treatment

The use of antipsychotics in the treatment of schizophrenia is often associated with the development of overweight and obesity, which poses a risk for the onset of many diseases and increases…
13. 3. 2024 Source: Modern Treatment of Schizophrenia
gravidity

Current findings on the treatment of gestational diabetes and DM2 in pregnancy with metformin

Recent reviews have shown that metformin is a safe alternative to insulin in the treatment of diabetes during pregnancy. For gestational diabetes (GDM) and type 2 diabetes mellitus (DM2), metformin…
12. 3. 2024 Source: Modern Treatment of Diabetes
metastatický karcinom prsu

Trastuzumab Deruxtecan in Patients with HER2+ Metastatic Breast Cancer

Last year, results of studies published in the Lancet journal demonstrated a significant clinical benefit of trastuzumab deruxtecan in patients with HER2+ metastatic breast cancer (mBC) pre-treated…
12. 3. 2024 Source: Ovarian and Breast Cancer
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