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CLL

Benefits of Time-Limited CLL Therapy

5. 3. 2024 Source: Chronic Lymphocytic Leukemia

The advent of new targeted molecules has significantly influenced the possibilities of therapy for chronic lymphocytic leukemia (CLL) and are now an integral part of treatment regimens, including the 1st line. Individual therapeutic approaches and strategies based on them have their advantages and disadvantages as well as their target patient group, but the concept of time-limited treatment is increasingly gaining ground. Therapy today is significantly individualized, and its optimal choice is based on the assessment of various circumstances…

srdce

Improving treatment outcomes of HF with preserved ejection fraction according to JACC: What does the success of gliflozins mean for the future?

The Journal of the American College of Cardiology (JACC) recently issued a scientific statement in which the authors thoroughly examined current knowledge on the epidemiology, pathophysiology,…
4. 3. 2024 Source: Heart Failure
úhradové podmínky

Current Reimbursement Conditions for the Dual Inhibitor IL-4/IL-13 Dupilumab

The biologic dupilumab is approved for the treatment of several diseases with type 2 inflammation. What is the current reimbursement situation in key indications? We summarize in the following brief…
4. 3. 2024 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
mozek

Digital Bridge Between the Brain and Spine: How an Implant Restored Walking Ability to a Paralyzed Patient −⁠ Case Study

When a spinal cord injury occurs, communication between the brain and peripheral nerves is interrupted, causing paralysis. Until recently, it was not possible to restore mobility for most of these…
4. 3. 2024 Source: medScope.pro
makak

A Cloned Monkey Survived to Adulthood for the First Time. Will We Soon Be Able to Clone Humans?

A macaque named ReTro, born as a result of a cloning experiment by Chinese scientists, has reached adulthood. This is the first such successful cloning that could pave the way for further primate…
4. 3. 2024 Source: medScope.pro
zlomenina kost

Can we properly manage osteoporotic fractures?

Osteoporotic fractures are associated with increased morbidity and mortality and often lead to an overall deterioration in the quality of life. We should not forget to diagnose osteoporosis in…
29. 2. 2024 Source: Osteoporosis – Trends in Sequential Therapy
kost

Meta-analysis of the Effectiveness of Romosozumab in the Treatment of Postmenopausal Osteoporosis

Osteoporosis is a prevalent disease with unmet therapeutic needs. Whether the anti-sclerostin antibody romosozumab can offer an effective improvement in osteoporosis treatment outcomes in…
29. 2. 2024 Source: Osteoporosis – Trends in Sequential Therapy
paranoidní schizofrenie_muž

Lurasidone in a Patient with Paranoid Schizophrenia and Asperger's Syndrome –⁠ A Case Study

Lurasidone is an effective and very gentle antipsychotic which is establishing a prominent position in modern psychopharmacotherapy. Its unique receptor profile makes it a suitable choice for…
27. 2. 2024 Source: Modern Treatment of Schizophrenia
hypotyreózy

Clinical Significance of Smaller Gaps Between Strengths of Levothyroxine Preparations in the Treatment of Hypothyroidism

Many levothyroxine preparations have relatively large intervals between doses (25 µg, 50 µg, and 75 µg), creating obstacles for some patients to achieve an optimal maintenance dose. The availability…
23. 2. 2024 Source: Thyroid Disorders
stitna zlaza

Generic Substitution of Levothyroxine in Practice

The active ingredient levothyroxine is found in a significant number of medicinal products (MP) in the Czech Republic. The question of its generic substitution remains current, primarily because the…
22. 2. 2024 Source: Thyroid Disorders
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