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Mechanisms Connecting Diabetes Mellitus and Obesity
Obesity has a close relationship with insulin resistance and diabetes mellitus (DM); weight gain is associated with a higher incidence of both type 1 and type 2 DM. In the development of type 2 DM, depletion of pancreatic β-cells plays a crucial role, which can no longer produce sufficient insulin to maintain glucose homeostasis. The development of diabetes is much more likely if β-cell failure is accompanied by increased insulin resistance. In obese patients, there is a higher proportion of unsaturated fatty acids, glycerol, pro-inflammatory cytokines,...
Venotonics in Hemorrhoid Therapy – Results of a Systematic Review
Hemorrhoids are among the most common pathological findings in the anorectal area, and their…
Diosmin and its application in the treatment of venous insufficiency
A number of procedures, including pharmacotherapy, are used in the treatment of chronic venous…
Efficacy and Safety of Gene Therapy Using Adeno-Associated Virus Vector in Patients with Choroideremia
Choroideremia (CHM) is a rare genetically conditioned retinal disease caused by mutations in the…
Results of ATTUNE Total Knee Replacement Implantation – Data from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man
The ATTUNE knee replacement system was fully introduced into clinical practice in 2013. Since then,…
Young man with nephrotic syndrome and portal vein thrombus successfully treated with edoxaban − case report
Venous thrombosis is one of the main complications of nephrotic syndrome (NS), though it is most…
Options of Anticoagulant Therapy During Pregnancy: Focus on Fondaparinux
The use of most medicinal products is limited during pregnancy either by known teratogenic effects…
Alternative to benzodiazepines or clomethiazole in the treatment of alcohol withdrawal syndrome?
Alcohol withdrawal syndrome (AWS) is a potentially life-threatening condition. A meta-analysis…
Importance of pH in Care for Stoma Patients
Maintaining good quality peristomal skin and preventing complications related to the stoma site are…
Combination of SGLT2 inhibitors with metformin in terms of mechanism of action
In the treatment of type 2 diabetes (T2D), metformin is recommended as the first-line drug alongside...