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The Importance of Early Diagnosis and Treatment of AATD in Preventing Pulmonary Emphysema

13. 7. 2020 Source: Deficiency of Alpha-1-Antitrypsin

Alpha-1 antitrypsin deficiency (AATD) is a risk factor for the development of various diseases, including pulmonary emphysema. Currently, it is significantly underdiagnosed, and the availability of effective treatment is a reason for conducting its screening. The Czech Pneumological and Phthisiological Society ČLS JEP (ČPFS) recommends examining AAT levels in all patients with irreversible obstructive ventilatory disorders of any origin, direct relatives of patients with AATD, and individuals with chronic liver disease of unclear origin. The…

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Deficit Alpha-1-Antitrypsin as an Underestimated Problem? What a Survey Among European Experts Revealed

Alpha-1-antitrypsin deficiency (AATD) is a congenital disorder caused by mutations in the SERPINA1 gene. Although it is very well described, it is considered underdiagnosed and undertreated. A recent…
13. 7. 2020 Source: Deficiency of Alpha-1-Antitrypsin
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Does Tofacitinib Improve Comorbid Depressive and/or Anxiety Symptoms in Patients with Rheumatoid Arthritis?

Depression and anxiety disorders are commonly observed in patients with rheumatoid arthritis and can lead to a reduction in quality of life, functional capacity, and, last but not least, to a lower…
9. 7. 2020 Source: Arthritis
Vyšetření pacientky magnetickou rezonancí.

Efficacy of Reduced Dose Tumor Necrosis Factor Inhibitors in Axial Spondyloarthritis

The introduction of tumor necrosis factor inhibitors marked a breakthrough in the treatment of axial spondyloarthritis and other autoimmune diseases. One disadvantage of using these drugs can be…
9. 7. 2020 Source: Arthritis
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Effect of Combination of Dorzolamide with Timolol for Wet Age-Related Macular Degeneration

In some eyes with wet age-related macular degeneration (AMD), exudation does not stop despite frequent intravitreal injections of vascular endothelial factor blockers (anti-VEGF). Adjuvant therapy…
3. 7. 2020 Source: Glaucoma
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Minimum and Optimal Factor Levels in Physically Active Hemophiliacs

Authors of a recently published study attempted to determine the value of minimum and optimal levels of coagulation factors in patients with severe hemophilia who engage in physical activities.
2. 7. 2020 Source: Hemophilia
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Tolerability and Efficacy of Eye Drops with and without Preservatives −⁠ A Comparison in Routine Clinical Practice

Insufficient patient compliance due to intolerance of the ocular preparation is a major reason for changing treatment, such as switching to preservative-free drops. The aim of the international…
29. 6. 2020 Source: Treatment of Glaucoma
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In vivo monitoring of corneal changes in patients treated with and without preservative-containing glaucoma medications

A study published last year by Italian authors monitored structural changes in the corneas of patients treated with preservative-free glaucoma medication for 3 years using confocal microscopy and…
29. 6. 2020 Source: Treatment of Glaucoma
Případová studie pacienta

Possibilities of Using a Topical Immunomodulator for Exacerbation of Atopic Eczema –⁠ Case Study

A 17-year-old high school student consulted a dermatologist due to the exacerbation of atopic eczema symptoms. The worsening occurred after dietary non-compliance and an acute upper respiratory tract…
26. 6. 2020 Source: Topical Treatment of Psoriasis
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Pregabalin Relieves Patients with Central Neuropathic Pain

Treatment of central neuropathic pain, whether caused by spinal cord or cerebral damage, is often lengthy and not always successful. Study results show that pregabalin may be a suitable alternative…
25. 6. 2020 Source: Neuropathic Pain
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