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Comparison of Pharmacological Properties of Micronized Diosmin and Hesperidin in the Treatment of Chronic Venous Insufficiency and Hemorrhoids
Diosmin and hesperidin belong to the group of bioflavonoids, which currently find wide application in the treatment of chronic venous insufficiency and hemorrhoidal disease. Both flavonoids have been described to have a similar, but still not fully understood mechanism of action. Nevertheless, diosmin significantly differs from hesperidin, especially in pharmacokinetic parameters, which makes it the main carrier of the effect of venotonics.

Topically administered tacrolimus does not increase cancer risk in children with atopic dermatitis
Topical therapy using corticosteroids or calcineurin inhibitors forms the main component of…

Are Topical Calcineurin Inhibitors Really Such Demons?
Some medications indeed have significant side effects, while others suffer from a bad reputation…

Case Study of a Patient with NSCLC − with Voting
Presented by: MUDr. Leona Koubková,
Pneumology Clinic, 2nd Faculty of Medicine, Charles University...

Dupilumab – The First Biologic Umbrellaing Type 2 Inflammation Treatment: How Does It Work and Who Is It For?
A new drug is entering the market for the treatment of atopic dermatitis, asthma, and chronic…

Interaction of the 'Big Five' Helps Predict Depression
Experts refer to the 'Big Five' as a personality model that encompasses the following five…

Effect of 3 Different Doses of Trazodone on QT Interval Length
Patients diagnosed with depression often also suffer from cardiovascular diseases, including heart…

What Did the Patent for the Synthesis of Highly Purified Trazodone Bring?
Trazodone is a modern antidepressant that is used in the treatment of various types of depression,…

Long-term Clinical and Radiological Results of Implantation of Cementless Corail Stem
The Corail femoral stem with extensive hydroxyapatite coating for cementless implantation was…

Immunotherapy of Cancer Diseases
Immunotherapeutic strategies have been successfully utilized recently in the treatment of various malignancies....