The Hradec Gastroenterology Days 2023 were traditionally held in March at the Educational Center of the Faculty of Medicine, Charles University, in the area of University Hospital Hradec Králové. The expert program included a lecture by MUDr. Libuše Husová, Ph.D., from the Cardio-surgical and Transplant Surgery Center Brno (CKTCH), who highlighted various situations that can arise during the treatment of primary biliary cholangitis (PBC) with three case studies.