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RETRO-TAS Study –⁠ Trifluridine/Tipiracil in Pretreated mCRC in Real-World Practice

25. 5. 2023 Source: Treatment of Gastrointestinal Carcinomas

How does trifluridine/tipiracil (FTD/TPI), which demonstrated efficacy in clinical trials in chemotherapy-refractory metastatic colorectal cancer (mCRC), fare in real-world practice? This was investigated by the authors of the Greek retrospective observational study RETRO-TAS.

screening

Study TACTIC –⁠ Efficacy and Safety of Trifluridine/Tipiracil in Pre-treated mCRC Patients in Real-world Practice

In the pivotal phase III RECOURSE randomized placebo-controlled study, therapy with trifluridine/tipiracil (FTD/TPI) was associated with improved overall survival and progression-free survival in…
25. 5. 2023 Source: Treatment of Gastrointestinal Carcinomas
karcinomplic

Incidence of Brain Metastases and Intracranial Activity of Sotorasib in Patients with NSCLC with G12C Mutation of the KRAS Oncogene

Sotorasib is the first targeted drug approved for the treatment of metastatic non-small cell lung cancer (NSCLC) with the G12C mutation of the KRAS oncogene. The newly published study presented below…
24. 5. 2023 Source: Lung Cancer
schizofrenie lékař a pacient

“Customized Schizophrenia Treatment”: Benefits of Therapeutic Innovations in Inpatient and Outpatient Care Thanks to Gentler Antipsychotics

In the field of schizophrenia treatment, the possibility of significantly greater individualization, brought about by gentler antipsychotics, is currently a hot topic. A major focus is the…
24. 5. 2023 Source: Modern Treatment of Schizophrenia
lecbaglaukomu

Pharmacotherapy of Glaucoma in a Nutshell According to the Latest Recommendations of the European Glaucoma Society

The European Glaucoma Society published its latest, 5th version of recommendations for the treatment of glaucoma in 2021. The following text, based on these recommendations, focuses in a nutshell on the...
18. 5. 2023 Source: Treatment of Glaucoma
hemofilie krevní testy

Model of Risk of Bleeding Associated with Physical Activity in Hemophiliacs with Factor and Non-Factor Treatment

In the treatment of hemophilia A, both FVIII concentrate replacement therapy and non-factor therapy are available today. However, there is no clinical data comparing the risk of bleeding associated…
18. 5. 2023 Source: Hemophilia
splenomegalie

When to Consider Gaucher Disease and How to Diagnose It Early and Correctly

Considering Gaucher disease (GD) as a cause of a patient's problems, especially in the case of splenomegaly and bleeding manifestations, is very important, regardless of age. Screening using the dry…
16. 5. 2023 Source: Rare Diseases in Hematology
mudr_Havrankova_Petra

COMMENTARY FROM PRACTICE: On Some Aspects of Care for Patients with Parkinson's Disease

What issues do we still encounter in the diagnosis and treatment of Parkinson's disease even today, despite medical advancements? How to fine-tune the management of care for these patients, facilitate...
15. 5. 2023 Source: Parkinson's Disease
Ceftazidim/avibaktam (CZA)

Detection of ceftazidime/avibactam-resistant Enterobacteriaceae strains using a new rapid test

Ceftazidime/avibactam (CZA) is a relatively new antibiotic with very good efficacy against carbapenem-resistant Enterobacteriaceae. Unfortunately, strains resistant to this antimicrobial treatment…
15. 5. 2023 Source: Anti-Infectives
lékeřská doporučení

Diagnosing Myelodysplastic Syndrome According to MDS Europe

In 2021, the European Hematology Association (EHA) endorsed the recommendations of the MDS Europe group for the diagnosis of myelodysplastic syndrome (MDS). MDS-RIGHT is a large European project…
15. 5. 2023 Source: medScope.pro
bilaterální karcinom prsu

Proton Therapy and Its Results in the Treatment of Bilateral Breast Cancer

Breast cancer is the most common malignant tumor disease in women, and its incidence sharply increases after the age of 50. Although its incidence shows a continuously increasing trend, the…
11. 5. 2023 Source: Proton Radiotherapy
obvaz doctor

Compression Therapy with Zinc Oxide Dressings in Dermatology

Zinc oxide dressings have a long-standing tradition and continue to find their place in modern dermatology. Compression therapy is the cornerstone of conservative treatment for chronic venous…
10. 5. 2023 Source: Wound Healing
pacient hlava

Metamizole in Pain Management for Patients with Subarachnoid Hemorrhage

A study by Czech authors from the University Hospital St. Anna in Brno, recently published in the British Journal of Neurosurgery, evaluated analgesic treatment in patients with subarachnoid…
10. 5. 2023 Source: Analgesia
orto kartacek

Comparison of the Effectiveness of Different Types of Toothbrushes in Orthodontic Patients

The aim of the study cited below was to evaluate the efficiency of a manual orthodontic brush, an electric toothbrush with an oscillating head, and a sonic toothbrush in controlling plaque,…
10. 5. 2023 Source: Dental Care
RS

Efficacy and Safety of Ozanimod in the Treatment of Relapsing-Remitting MS

The sphingosine-1-phosphate receptor (S1PR) modulator ozanimod has recently been approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). We summarize the current knowledge…
9. 5. 2023 Source: Modulation of S1P in the Treatment of Autoimmune Diseases
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