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Are SGLT2 Inhibitors Only Suitable for the Treatment of Diabetes?
19. 2. 2020 Source: Modern Treatment of DiabetesSGLT2 inhibitors, or gliflozins, are effective antidiabetic drugs that have shown nephroprotective and cardioprotective effects in diabetics, repeatedly demonstrated in clinical trials. At the European Cardiology Congress in September 2019 in Paris, results were presented from the DAPA-HF study, where dapagliflozin became the first SGLT2 inhibitor to show benefits in patients with heart failure with reduced ejection fraction of the left ventricle, regardless of whether they had type 2 diabetes or not. The study thus offered a completely new…
How to Manage Thromboprophylaxis in Obese and Extremely Obese Patients?
Doctors often address the question of how to dose thromboprophylaxis in overweight individuals. The goal is to ensure effective protection against thrombotic complications in stressful situations,…18. 2. 2020 Source: Thromboprophylaxis
Positive Effect of Pregabalin Not Only on Neuropathic Pain in Patients with Spinal Cord Injury
Spinal cord injury is often accompanied by painful conditions. A study published in the prestigious journal Neurology demonstrated that administering pregabalin to these patients can bring more than…18. 2. 2020 Source: Neuropathic Pain
Pregabalin in the Hands of a General Practitioner
A recent Cochrane systematic review by authors from Oxford University examined the effect of pregabalin in the treatment of postherpetic neuralgia and diabetic neuropathy – conditions that general…18. 2. 2020 Source: Neuropathic Pain
Can We Lump All Gabapentinoids Together?
General practitioners often encounter peripheral neuropathic pain in their practice. One of the primary modalities for treating both painful diabetic neuropathy and postherpetic neuralgia is…18. 2. 2020 Source: Neuropathic Pain
Valproate for Acute Mania: Is Practice Really Evidence-Based and Recommended?
Authors from the University of Western Ontario conducted an audit in an acute psychiatric intake unit to determine whether the prescription of valproate there corresponded to evidence-based…18. 2. 2020 Source: Bipolar Disorder
Low-Molecular-Weight Heparin as Adjuvant Therapy in Small-Cell Lung Cancer − Results of the RASTEN Study
Several studies and meta-analyses in the past have pointed to a possible positive effect of low-molecular-weight heparins (LMWH) in the treatment of cancer. The RASTEN study therefore focused on the…18. 2. 2020 Source: Thromboprophylaxis
Efficacy and Speed of Pain Relief in Rheumatoid Arthritis When Adding Baricitinib to Methotrexate
The phase III clinical trial RA-BEAM conducted in patients with rheumatoid arthritis (RA) inadequately controlled by methotrexate demonstrated the benefit of adding baricitinib or adalimumab compared…17. 2. 2020 Source: Biological Treatment
Can NOACs 'Compete' with Well-Managed Warfarin Treatment? Retrospective Data from Swedish Registers
The efficacy and safety of new oral anticoagulants (NOACs) in stroke prevention in atrial fibrillation have been proven by numerous studies. The quality of warfarin treatment, assessed by the 'time…17. 2. 2020 Source: Anticoagulant Treatment
Documented Cardiovascular Benefit of Empagliflozin in New American Diabetes Treatment Guidelines
Two leading overseas medical professional societies, the American Diabetes Association (ADA) and the American Association of Clinical Endocrinologists (AACE), released new recommendations for diabetes...14. 2. 2020 Source: Diabetes
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