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Effect of Initiation of Warfarin Therapy on the Risk of Ischemic Stroke

17. 7. 2020 Source: Anticoagulant Treatment

Anticoagulant therapy is essential in patients with atrial fibrillation for the prevention of thromboembolic events. Warfarin is a highly effective anticoagulant, but the introduction of new oral anticoagulants (NOACs) has offered certain advantages over it. Shortly after starting warfarin therapy, patients have repeatedly been shown to have a paradoxically increased risk of developing ischemic stroke. The aim of the study presented below was to determine whether this increase in risk is associated with the initiation of anticoagulant therapy.

žena lékařka doktorka konzultace špatné zprávy

Current Indication Criteria for Testing Mutations in BRCA1 and BRCA2 Genes in Breast and Ovarian Cancer

Testing the mutation status of the BRCA1/2 genes can be beneficial for prevention, and in the case of already detected breast and/or ovarian cancer, also for direct treatment. We provide a brief…

16. 7. 2020 Source: Ovarian and Breast Cancer

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Aclidinium bromide improves the quality of life for COPD patients

The ON-AIR study conducted in real practice demonstrated the benefits of aclidinium bromide for the quality of life of patients with chronic obstructive pulmonary disease (COPD). It also assessed the…

15. 7. 2020 Source: Treatment of Asthma and COPD

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Study AMPLIFY Confirmed Safety and Efficacy of Fixed Combination Aclidinium/Formoterol in COPD Therapy

The randomized double-blind phase III AMPLIFY study compared the efficacy of a fixed combination of formoterol/aclidinium with monotherapy of the individual components or with tiotropium in patients…

15. 7. 2020 Source: Treatment of Asthma and COPD

Efficacy of L. reuteri DSM 17938 in Treating Acute Gastroenteritis in Children

Diarrheal diseases are among the most common causes of death worldwide in children under 5 years of age. Effective and timely treatment is crucial in the case of acute gastroenteritis (AGE), which is…

15. 7. 2020 Source: GI, colic and microbiome

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The Importance of Early Diagnosis and Treatment of AATD in Preventing Pulmonary Emphysema

Alpha-1 antitrypsin deficiency (AATD) is a risk factor for the development of various diseases, including pulmonary emphysema. Currently, it is significantly underdiagnosed, and the availability of…

13. 7. 2020 Source: Deficiency of Alpha-1-Antitrypsin

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Deficit Alpha-1-Antitrypsin as an Underestimated Problem? What a Survey Among European Experts Revealed

Alpha-1-antitrypsin deficiency (AATD) is a congenital disorder caused by mutations in the SERPINA1 gene. Although it is very well described, it is considered underdiagnosed and undertreated. A recent…

13. 7. 2020 Source: Deficiency of Alpha-1-Antitrypsin

Does Tofacitinib Improve Comorbid Depressive and/or Anxiety Symptoms in Patients with Rheumatoid Arthritis?

Depression and anxiety disorders are commonly observed in patients with rheumatoid arthritis and can lead to a reduction in quality of life, functional capacity, and, last but not least, to a lower…

9. 7. 2020 Source: Arthritis

Vyšetření pacientky magnetickou rezonancí.

Efficacy of Reduced Dose Tumor Necrosis Factor Inhibitors in Axial Spondyloarthritis

The introduction of tumor necrosis factor inhibitors marked a breakthrough in the treatment of axial spondyloarthritis and other autoimmune diseases. One disadvantage of using these drugs can be…

9. 7. 2020 Source: Arthritis

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Effect of Combination of Dorzolamide with Timolol for Wet Age-Related Macular Degeneration

In some eyes with wet age-related macular degeneration (AMD), exudation does not stop despite frequent intravitreal injections of vascular endothelial factor blockers (anti-VEGF). Adjuvant therapy…

3. 7. 2020 Source: Glaucoma

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Minimum and Optimal Factor Levels in Physically Active Hemophiliacs

Authors of a recently published study attempted to determine the value of minimum and optimal levels of coagulation factors in patients with severe hemophilia who engage in physical activities.

2. 7. 2020 Source: Hemophilia

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Tolerability and Efficacy of Eye Drops with and without Preservatives −⁠ A Comparison in Routine Clinical Practice

Insufficient patient compliance due to intolerance of the ocular preparation is a major reason for changing treatment, such as switching to preservative-free drops. The aim of the international…

29. 6. 2020 Source: Treatment of Glaucoma

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In vivo monitoring of corneal changes in patients treated with and without preservative-containing glaucoma medications

A study published last year by Italian authors monitored structural changes in the corneas of patients treated with preservative-free glaucoma medication for 3 years using confocal microscopy and…

29. 6. 2020 Source: Treatment of Glaucoma

Případová studie pacienta

Possibilities of Using a Topical Immunomodulator for Exacerbation of Atopic Eczema –⁠ Case Study

A 17-year-old high school student consulted a dermatologist due to the exacerbation of atopic eczema symptoms. The worsening occurred after dietary non-compliance and an acute upper respiratory tract…

26. 6. 2020 Source: Topical Treatment of Psoriasis

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Pregabalin Relieves Patients with Central Neuropathic Pain

Treatment of central neuropathic pain, whether caused by spinal cord or cerebral damage, is often lengthy and not always successful. Study results show that pregabalin may be a suitable alternative…

25. 6. 2020 Source: Neuropathic Pain

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