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Starší doktor u počítače vysvětluje mladé pacientce její zdravotní stav.

What is the significance of hormones in the pathophysiology of migraine?

27. 7. 2020 Source: Migraine

Migraine is a complex neurovascular disease characterized by the dysfunction of the nociceptive trigeminovascular system in its pathophysiology. Its prevalence is 2-3 times higher in women than in men. The cause of this difference has not yet been fully elucidated, but it appears that the fluctuation of ovarian hormone levels and its influence on CGRP plays an important role. The following article summarizes findings on the hormonal influence of migraine and also discusses new prophylactic drugs –⁠ anti-CGRP antibodies.

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When to Initiate Dabigatran Therapy in Patients with Atrial Fibrillation After First Ischemic Stroke?

After a cardioembolic ischemic stroke (iCMP), approximately 5% of patients experience a recurrence within the first 14 days without anticoagulant therapy. The aim of the retrospective observational…
21. 7. 2020 Source: Anticoagulant Treatment
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Trazodone as an Effective Medicine in the Therapy of Depression and Insomnia

Trazodone (Trittico®) is a medicine indicated for the treatment of depression, which has also been shown to have a positive effect in treating other associated conditions. In practice, however, the…
19. 7. 2020 Source: Depression and Anxiety
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Inflammation, Polyunsaturated Fatty Acids and Their Significance in the Development and Treatment of Depression

Depression is currently a highly discussed disease with a prevalence that is likely to rise. Therefore, scientists are focusing on potential causes and new treatment modalities. It has been shown…
19. 7. 2020 Source: Depression and Anxiety
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What Next for Patients with CLL After Stopping Venetoclax?

Standard care for untreated patients with chronic lymphocytic leukemia (CLL) is therapy based on venetoclax. However, managing further treatment when venetoclax needs to be discontinued remains a…
17. 7. 2020 Source: Chronic Lymphocytic Leukemia
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Effect of Initiation of Warfarin Therapy on the Risk of Ischemic Stroke

Anticoagulant therapy is essential in patients with atrial fibrillation for the prevention of thromboembolic events. Warfarin is a highly effective anticoagulant, but the introduction of new oral…
17. 7. 2020 Source: Anticoagulant Treatment
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Current Indication Criteria for Testing Mutations in BRCA1 and BRCA2 Genes in Breast and Ovarian Cancer

Testing the mutation status of the BRCA1/2 genes can be beneficial for prevention, and in the case of already detected breast and/or ovarian cancer, also for direct treatment. We provide a brief…
16. 7. 2020 Source: Ovarian and Breast Cancer
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Aclidinium bromide improves the quality of life for COPD patients

The ON-AIR study conducted in real practice demonstrated the benefits of aclidinium bromide for the quality of life of patients with chronic obstructive pulmonary disease (COPD). It also assessed the…
15. 7. 2020 Source: Treatment of Asthma and COPD
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Study AMPLIFY Confirmed Safety and Efficacy of Fixed Combination Aclidinium/Formoterol in COPD Therapy

The randomized double-blind phase III AMPLIFY study compared the efficacy of a fixed combination of formoterol/aclidinium with monotherapy of the individual components or with tiotropium in patients…
15. 7. 2020 Source: Treatment of Asthma and COPD
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Efficacy of L. reuteri DSM 17938 in Treating Acute Gastroenteritis in Children

Diarrheal diseases are among the most common causes of death worldwide in children under 5 years of age. Effective and timely treatment is crucial in the case of acute gastroenteritis (AGE), which is…
15. 7. 2020 Source: GI, colic and microbiome
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The Importance of Early Diagnosis and Treatment of AATD in Preventing Pulmonary Emphysema

Alpha-1 antitrypsin deficiency (AATD) is a risk factor for the development of various diseases, including pulmonary emphysema. Currently, it is significantly underdiagnosed, and the availability of…
13. 7. 2020 Source: Deficiency of Alpha-1-Antitrypsin
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Deficit Alpha-1-Antitrypsin as an Underestimated Problem? What a Survey Among European Experts Revealed

Alpha-1-antitrypsin deficiency (AATD) is a congenital disorder caused by mutations in the SERPINA1 gene. Although it is very well described, it is considered underdiagnosed and undertreated. A recent…
13. 7. 2020 Source: Deficiency of Alpha-1-Antitrypsin
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Does Tofacitinib Improve Comorbid Depressive and/or Anxiety Symptoms in Patients with Rheumatoid Arthritis?

Depression and anxiety disorders are commonly observed in patients with rheumatoid arthritis and can lead to a reduction in quality of life, functional capacity, and, last but not least, to a lower…
9. 7. 2020 Source: Arthritis
Vyšetření pacientky magnetickou rezonancí.

Efficacy of Reduced Dose Tumor Necrosis Factor Inhibitors in Axial Spondyloarthritis

The introduction of tumor necrosis factor inhibitors marked a breakthrough in the treatment of axial spondyloarthritis and other autoimmune diseases. One disadvantage of using these drugs can be…
9. 7. 2020 Source: Arthritis
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Effect of Combination of Dorzolamide with Timolol for Wet Age-Related Macular Degeneration

In some eyes with wet age-related macular degeneration (AMD), exudation does not stop despite frequent intravitreal injections of vascular endothelial factor blockers (anti-VEGF). Adjuvant therapy…
3. 7. 2020 Source: Glaucoma
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