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Transthyretin – More Than a Thyroxine Transporter
Transthyretin (TTR) is an extracellular protein whose main role is to transport thyroxine and retinol in the body and brain. TTR tends to form amyloid deposits, which can lead to systemic disease known as TTR amyloidosis. Recently, it has been shown that this protein has a much wider spectrum of activities in the organism than previously thought.
Patient with a History of DOAC Usage in Neurological ICU with Stroke – Case Study
How should we approach patients with a stroke who are taking direct oral anticoagulants (DOACs) and correctly assess the situation? When should we administer the available antidote according to…
Critical Overview of Clinical Studies on EHL FVIII Preparations
An international team of experts recently published a comprehensive work evaluating the methodology used in clinical trials of various extended half-life (EHL) factor VIII (FVIII) products. Their…
Overview of Regimen Measures for House Dust Mite Allergy
House dust mite allergy is one of the significant causes of respiratory allergies in both children and adult patients. In addition to pharmacological treatment, the cornerstone of therapy also…
Long-term Safety of Dupilumab in Adult Patients with Moderate to Severe Atopic Dermatitis
Moderate to severe atopic dermatitis (AD) often requires systemic therapy. The long-term safety of dupilumab in patients with this condition was evaluated in an open-label extension (OLE) of the…
Treatment of Tumors Using Ultrasound? The First Results of the Use of Histotripsy Look Promising
Histotripsy represents a new therapeutic method that allows the non-invasive removal of tumor tissue using the principle of so-called ultrasound cavitation. The method has been successfully tested in…
Tiapride versus Haloperidol in the Therapy of Aggressiveness and Agitation in Elderly Patients with Cognitive Impairment
Acute restlessness, agitation, and aggression can be associated with psychiatric disorders but also be manifestations of somatic illnesses. Psychomotor agitation combined with disorientation is…
Non-Invasive Diagnosis of Cardiac Amyloidosis
Cardiac amyloidosis has always been considered a rare pathology. However, thanks to advancements in imaging methods and laboratory tests, it is now evident that it might be responsible for a larger…
Memantine, Acetylcholinesterase Inhibitors, and Their Combination in the Treatment of Alzheimer's Disease − Findings from Meta-Analyses
Is memantine, an acetylcholinesterase inhibitor (donepezil), or their combination more advantageous in the therapy of Alzheimer's disease? Two meta-analyses tried to answer this question, and we…
Long-term Efficacy, Safety, and Tolerability of Normal Human IgG with Facilitated Absorption in Patients with Humoral Immunodeficiency
The treatment of patients with humoral immunodeficiency is long-term and therefore needs to be not only effective but also safe and well-tolerated. Below, we present the outcomes from an Italian…
fSCIG in Elderly Patients with PID or SID in Real Clinical Practice
The work of a team of German and Dutch authors presents data on the real clinical use of 10% subcutaneous immunoglobulin facilitated by hyaluronidase (fSCIG) in elderly patients with primary (PID) or…
Current NCCN Recommendations for Classification and Risk Symptoms in SLL/CLL
The new recommendations from the National Comprehensive Cancer Network (NCCN) regarding chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) from August 2022 also include a brief…
Electronic Cigarettes as an Alternative Option for Quitting Smoking?
Diseases caused by smoking tobacco products are a significant cause of global morbidity and mortality. One of the options for quitting smoking is electronic cigarettes, which, although not entirely…
Diabetes mellitus and heart failure − interconnected units with complex pathogenesis
Diabetes mellitus (DM) represents a significant risk factor for the development of heart failure. The pathogenesis of this condition is very complex, involving hyperglycemia and other metabolic…
Teriflunomide "under the microscope" or what it's like to live with MS in the North
The Teri-LIFE study examined teriflunomide very comprehensively. How does it manage to affect the quality of life of patients with multiple sclerosis (MS) according to data from real clinical…