News
Prof. Miloš Broďák: Introduction of new drugs has significantly improved results even in progressive and recurrent prostate cancers
The prognosis and treatment outcomes for patients with various stages of prostate cancer have significantly improved over the past two decades thanks to a number of new or improved modalities of diagnosis and therapy. We should soon benefit from newly introduced screening, or early detection programs, for these tumors. We briefly speak with Prof. MUDr. Miloš Broďák, Ph.D., head of the Urology Clinic of the Medical Faculty of Charles University and University Hospital Hradec Králové, about the latest advancements and challenges in this field,…
Subcutaneous zilucoplan – the end of necessary “trips” to the hospital for myasthenia gravis patients?
A study recently published in Lancet Neurology demonstrated the efficacy and safety of the subcutaneously administered complement component C5 inhibitor – zilucoplan – in the treatment of myasthenia…
Wireless Smart Devices Monitor Health by Detecting Sounds
The human body continuously emits various forms of acoustic-mechanical signals that can provide important information about its health. Researchers from Northwestern University in the USA have…
Economic Burden and Loss of Quality of Life as a Consequence of Dry Eye Syndrome
Canadian authors evaluated the direct and indirect financial costs associated with dry eye syndrome (DED − dry eye disease) and the impact of this condition on the quality of life (QoL) of patients.…
Advances in the Treatment of Myasthenia Gravis on the Horizon
The research of new drugs for the generalized form of myasthenia gravis has made significant progress in recent years. How is the new specific therapy performing? And are we heading towards a radical…
Biocompatibility of 3D Printed Materials – Their Comparison, Legislation, and Practice
Printing three-dimensional (3D) objects brings new possibilities for producing personalized implants, prosthetics, and other medical devices in healthcare. One area where this technology can improve…
Pegylated Liposomal Irinotecan + 5-FU/LV in the Treatment of mPDAC in Czech Clinical Practice – Results from the VILP Registry
At last year's annual congress of the European Society for Medical Oncology (ESMO) and this year's 15th PragueONCO, results from the Czech VILP registry were presented. This registry collected data…
Bimekizumab in 3rd Line Biological Treatment After Risankizumab Failure – Case Study
The possibilities of biological therapy for severe forms of psoriasis are very broad today. Achieving remission or reducing disease activity by 90-100% from the baseline state (PASI 90-100) is highly...
How Does Artificial Intelligence Help in Drug Development?
In recent years, technologies leveraging artificial intelligence have transitioned from potentially interesting novelties to real clinical development programs. What can artificial intelligence offer…
Improvement in social functioning of patients with schizophrenia during treatment with lurasidone
A beneficial impact on social functioning is an important outcome of schizophrenia treatment. A recently published Japanese study is the first to demonstrate the efficacy of lurasidone compared to…
What to add to amlodipine when it alone is not enough for hypertension?
Treating hypertension is a daily task for not only general practitioners and cardiologists. Polish doctors evaluated the effect of adding bisoprolol on the blood pressure of patients with…
Effect of Extended-Release Metformin on Cognitive Functions in Older Frail Women with Diabetes and Hypertension
Women have a higher risk of geriatric frailty regardless of age and menopausal status. This risk further increases with the presence of diabetes and hypertension, which also elevate the risk of…
ACC 2023 Expert Consensus: How to Optimize Diagnosis and Treatment of Heart Failure with Preserved EF LK
Heart failure (HF) remains a significant cause of morbidity and mortality, with the incidence and prevalence of HF with preserved left ventricular ejection fraction (HFpEF) rising. The following…
Causes, Consequences, and Solutions to Weight Gain in Schizophrenia Treatment
The use of antipsychotics in the treatment of schizophrenia is often associated with the development of overweight and obesity, which poses a risk for the onset of many diseases and increases…