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Early Effect of Once-a-Day Trazodone in the Treatment of Major Depressive Disorder
24. 11. 2021 Source: Depression and AnxietyMost antidepressants have a delayed onset of action, reaching therapeutically effective levels only several weeks after the start of treatment. Trazodone is characterized by a specific mechanism of action and a rapid onset of therapeutic effect. A newly published analysis evaluated the available clinical data regarding the early effect of once-a-day trazodone in patients with Major Depressive Disorder (MDD).
Gene Therapy for Hemophilia A: What is the Expression of Factor VIII Using the Adeno-Associated Viral Vector SPK-8011?
The goal of gene therapy for hemophilia A is to safely transfer stable and durable expression of coagulation factor VIII (FVIII), which predictably improves the bleeding phenotype at the lowest…24. 11. 2021 Source: Quality Life Even with Hemophilia
Von Willebrand Disease in Women
Even in the context of gynecological issues, it is sometimes necessary to consider a hematological etiology of difficulties. The recommendations of the American College of Obstetricians and…23. 11. 2021 Source: Von Willebrand Disease
Biosimilar Drugs in Oncology
8 of the 10 most expensive drugs on the market are used in the treatment of cancer. Rising healthcare costs in recent decades have created a need to find strategies to limit these costs. Biosimilar…22. 11. 2021 Source: Oncological Treatment
Pharmacotherapy of Chronic Heart Failure with Reduced EF LV - Latest ESC Recommendations
The European Society of Cardiology (ESC) issued an update in 2021 for the diagnosis and treatment of heart failure. We summarize the essential points regarding the pharmacotherapy of chronic heart…22. 11. 2021 Source: Chronic Heart Failure and Lipidology
Administration of aPCC as a Prevention of Bleeding After Major Cardiac Surgical Procedures
The possibility of actively preventing severe bleeding after a major cardiac surgical procedure using cardiopulmonary bypass (CPB) by administering a concentrate of activated procoagulant complex…22. 11. 2021 Source: Hemophilia
Neutralizing Antibodies Against Emicizumab – Detailed Analysis Based on a Case Study
Japanese authors investigated the mechanism of reduced efficacy of emicizumab in an adult patient with hemophilia A and an inhibitor, whose treatment was discontinued due to repeated bleeding…22. 11. 2021 Source: Hemophilia
HAE and its Management in Pediatric Patients
Hereditary angioedema (HAE) can be encountered in the emergency room as well as in specialist practices. Patients with this rare disease are often incorrectly diagnosed with other, more common conditions,...19. 11. 2021 Source: Hereditary Angioedema
HAE in the Otolaryngologist's Office: How to Handle a Laryngeal Attack?
Hereditary angioedema (HAE) can be encountered in emergency rooms and specialist offices. Patients with this rare disorder are often misdiagnosed with a more common condition, and they may learn their...19. 11. 2021 Source: Hereditary Angioedema
Cell-Based Implant as a Stable System for Biological Therapy Delivery
A team of scientists from Washington University in St. Louis focused on the possibility of delivering biological inhibitors for the treatment of rheumatoid arthritis using modified induced…19. 11. 2021 Source: Arthritis
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