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Postoperative Bleeding in Children with Hypofibrinogenemia Induced by Cardiopulmonary Bypass
7. 7. 2022 Source: Life-threatening BleedingPatients undergoing cardiac surgery with the use of cardiopulmonary bypass are at risk of up to a 40% reduction in plasma fibrinogen levels, with subsequent risk of perioperative bleeding. Children undergoing surgery for congenital heart defects are even more sensitive to the reduction in fibrinogen. What are the possible solutions, and is any one of them significantly better?
Experiences with the Treatment of Coagulopathy in Obstetrics – ROTEM-Guided Algorithm
An observational study from a hospital in Liverpool, UK, was published in the journal Anaesthesia, where they implemented a bleeding management algorithm for obstetric procedures based on rotational…7. 7. 2022 Source: Life-threatening Bleeding
Incidence and Risk Factors of Community-Acquired Pneumonia in Hematologic Oncologic Patients
Patients with hematologic malignancies are at higher risk of infectious diseases, particularly community-acquired pneumonia, due to immunosuppression. However, recent data providing information on…5. 7. 2022 Source: Anti-Infectives
Summary of New American Recommendations for Heart Failure Management
This year, the American Heart Association (AHA), the American College of Cardiology (ACC), and the Heart Failure Society of America (HFSA) released joint recommendations for the diagnosis and…28. 6. 2022 Source: Heart Failure
Full Compensation of Seizures as the Main Goal of Epilepsy Therapy: Will Patients Achieve It More Easily Than 20 Years Ago?
What is the relationship between the quality of life of patients and the degree of seizure compensation? Have the new antiepileptics (ASM) developed over the last decades improved the overall success…28. 6. 2022 Source: Epilepsy
Safety Profile of Metamizole – A Systematic Review
Metamizole is a long-established non-steroidal analgesic used for acute and chronic pain management. A systematic review of the literature published in the Journal of Clinical Pharmacy and…28. 6. 2022 Source: Analgesia
Early and effective treatment of PBC significantly reduced the need for liver transplantation due to this disease
Current European and Czech guidelines include obeticholic acid (OCA) as the only registered option for 2nd line treatment of primary biliary cholangitis (PBC). In the Czech Republic, it is approved…23. 6. 2022 Source: Primary Biliary Cholangitis
Iron Deficiency and Administration of Ferric Carboxymaltose in Patients with Heart Failure
Iron deficiency is very common in patients with heart failure and is associated with exercise intolerance, reduced quality of life, increased mortality, and higher risk of hospitalization, regardless…21. 6. 2022 Source: Iron Deficiency and Anemia
Does empagliflozin improve the overall health of patients with heart failure with reduced LVEF?
A recently published secondary analysis of the EMPEROR-Reduced study is based mainly on the results of the KCCQ-23 questionnaire, which assesses the patient's health status from their perspective.…21. 6. 2022 Source: Heart Failure
Comparison of Dabigatran and Vitamin K Antagonists in Patients with Atrial Fibrillation in Real-World Practice
The final 3-year results of the GLORIA-AF study conducted in real-world practice with patients newly diagnosed with atrial fibrillation show a lower incidence of major bleeding and lower overall…21. 6. 2022 Source: Anticoagulant Treatment
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