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Pharmacokinetics of Concentrates for the Treatment of von Willebrand’s Disease

14. 11. 2022 Source: Von Willebrand Disease

Von Willebrand's disease (vWD) is characterized by a deficiency or reduced functional capacity of von Willebrand factor (vWF) and, in more severe cases, by a deficiency of coagulation factor VIII (FVIII). Treatment usually requires repeated infusions of vWF and FVIII concentrate, with available products having different factor ratios. Repeated infusions of concentrates can lead to different FVIII exposures when using different products. The pharmacokinetics of two products with varying vWF and FVIII ratios have been compared in experimental…

atopická dermatitida_dítě

New Therapeutic Options in Light of Current Knowledge on the Pathogenesis of Atopic Dermatitis

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intense itching and recurrent eczematous lesions. AD is diagnosed in 2 out of 10 children and often persists into…
14. 11. 2022 Source: Biological Treatment
ibs micro

Potential of Aloe to Reduce Severity of Symptoms in Patients with IBS −⁠ What Emerged from the Analysis of Fecal Microflora and Metabolite Profiles?

Current treatment options for irritable bowel syndrome (IBS −⁠ irritable bowel syndrome) are relatively limited. This increases interest in complementary and alternative therapy options with plant…
12. 11. 2022 Source: Irritable Bowel Syndrome
nemocné srdce leky praxe

ESC 2022: SGLT2 Inhibitors as Hope for HFpEF: How to Implement Them in Practice?

Patients with heart failure (HF) can significantly benefit from the inclusion of sodium-glucose co-transporter 2 inhibitors (SGLT2i, i.e., gliflozins) in their treatment strategy according to current…
10. 11. 2022 Source: Heart Failure
gingivitidou

The Importance of Limosilactobacillus reuteri in Administration to Diabetics with Gingivitis

We summarize the results of a clinical study on the effect of probiotics containing Limosilactobacillus reuteri on the improvement of gingivitis in patients with diabetes. It has been proven that the…
10. 11. 2022 Source: GI, colic and microbiome
compression stocking on her leg

Effectiveness of Compression Therapy in Patients with Leg Ulcers

Up to 2% of the population suffers from leg ulcers. The standard treatment for ulcers of venous etiology is compression. The following French study, whose results were recently published in the …
8. 11. 2022 Source: Wound Healing
výzkum krve

Rurioctocog Alfa Pegol vs. Non-factor Therapy –⁠ Report from Real Clinical Practice

The standard treatment for hemophilia A is the prophylactic administration of coagulation factor VIII (FVIII) concentrate. Recently, some hemophiliacs have also been switched to prophylaxis with…
8. 11. 2022 Source: Hemophilia
central nervous system

Lorlatinib in a Patient with Meningeal Carcinomatosis –⁠ Case Report

The prognosis of patients with meningeal carcinomatosis is unfavorable. The following case report demonstrates how a targeted mechanism of action and optimal drug penetration into the central nervous…
6. 11. 2022 Source: Genetic Profile and Treatment of NSCLC
roztroušená skleróza mozek

Tailored Treatment. Who is Teriflunomide Suitable For?

The authors of the recently published study cited below not only focused on the safety and efficacy of teriflunomide in real-world clinical practice but also on the risk factors for its insufficient…
3. 11. 2022 Source: Multiple Sclerosis
roztroušená skleróza mozek

The Future of Multiple Sclerosis –⁠ Time for a Change in Classification?

What are the latest findings on the etiopathogenesis of multiple sclerosis? Are they reflected in the current classification? And what will future therapy look like?
3. 11. 2022 Source: Multiple Sclerosis
srdce kardiologie výzkum

Protective Effect of SGLT2 Inhibitors on Heart Muscle Function -⁠ Findings from a Recent Meta-analysis

Sodium-glucose cotransporter 2 inhibitors (SGLT2i, i.e., gliflozins) primarily offer the ability to achieve very good glycemic control with a low risk of hypoglycemia. Their undeniable advantage,…
3. 11. 2022 Source: Heart Failure
životní styl diabetes

Efficacy of Conventional and Intensified Lifestyle Interventions in Individuals with Prediabetes According to Risk Level

Lifestyle changes can prevent the development of type 2 diabetes in individuals with prediabetes, but according to current findings, these measures fail for a significant portion of study…
2. 11. 2022 Source: Modern Treatment of Diabetes
predibates tablety injekce

Metformin with Extended Release in the Treatment of Prediabetes

The benefit of metformin in preventing the development of diabetes in people with prediabetes has been demonstrated in clinical studies. However, these studies evaluated immediate-release metformin,…
2. 11. 2022 Source: Modern Treatment of Diabetes
Antipsychotika

Meta-analysis of the Metabolic Effects of Second-generation Antipsychotics

Second-generation antipsychotics used in the therapy of schizophrenia exhibit varying metabolic profiles. A recently conducted meta-analysis by Italian authors investigated the impact of…
1. 11. 2022 Source: Modern Treatment of Schizophrenia
metabolický syndrom

Prevalence of Metabolic Syndrome During 1 Year After the First Episode of Psychosis

Portuguese authors elucidated the high prevalence of metabolic syndrome and adverse metabolic parameters in individuals with the first episode of psychosis. Moreover, it significantly increased…
1. 11. 2022 Source: Modern Treatment of Schizophrenia
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