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Pertuzumab significantly extends the life of patients with metastatic breast cancer

28. 4. 2020 Source: Breast Carcinoma

The final results of the CLEOPATRA clinical trial show that patients with HER2-positive metastatic breast cancer achieve 8-year overall survival of 37% with the targeted treatment combination of pertuzumab + trastuzumab + docetaxel.

medicína žena břicho vaječníky menstruace karcinom bolest těhotenství

Maintenance treatment with oral olaparib in women with BRCA1/2 mutation and relapsed ovarian cancer

In a phase III study published in the journal Lancet Oncology, data on the effectiveness of olaparib in patients with ovarian cancer and BRCA1/2 mutation were evaluated. The poly(ADP-ribose)…
27. 4. 2020 Source: Ovarian and Breast Cancer
fibrilace_sini_zaneseni_katetru_kardiologie

The Benefit of Dabigatran Over Warfarin Is Greater in Patients with Atrial Fibrillation and Diabetes Than in Nondiabetics

As early as 2015, an analysis of the results of the RE-LY study in patients with atrial fibrillation showed that the reduction in absolute risk of embolic events with dabigatran compared to warfarin…
24. 4. 2020 Source: Anticoagulant Treatment
citrusy strom rostlina příroda zahrada pomeranče ovoce

Positive Effect of Diosmin on Venous Disease in Terms of Factors Responsible for Angiogenesis

A study published last year monitored the impact of diosmin on laboratory and clinical parameters related to the pathophysiology of chronic venous disease in patients.
23. 4. 2020 Source: Venous Insufficiency
křečové žíly nohy žena medicína

Diosmin and Hesperidin: What Does Pharmacokinetics Show?

Flavonoids are plant-derived compounds that have a number of beneficial pharmacological effects. Among the most well-known flavonoids, alongside rutin, are diosmin and hesperidin, which are used as…
23. 4. 2020 Source: Venous Insufficiency
Pacient_chemoterapie

Obinutuzumab and Early Progression of Patients with Previously Untreated Follicular Lymphoma −⁠ Analysis of Data from the GALLIUM Study

The GALLIUM study demonstrated longer progression-free survival (PFS) in patients with previously untreated follicular lymphoma (FL) treated with obinutuzumab compared to rituximab. The aim of the…
23. 4. 2020 Source: Non-Hodgkin Lymphomas and CLL
ledvina_ledviny

Impact of Dabigatran and Warfarin Treatment on the Risk of Acute Kidney Injury in Patients with Atrial Fibrillation

What clinical characteristics in patients with non-valvular atrial fibrillation may indicate a higher risk of acute kidney injury? Does the modality of anticoagulation therapy play a role in its…
23. 4. 2020 Source: Anticoagulant Treatment
konzultace léčby

High-Dose Cyclophosphamide in Hard-to-Treat Patients with B-NHL

For hard-to-treat patients with non-Hodgkin lymphoma, cyclophosphamide administered in one or two cycles can help bridge the period needed to obtain other effective treatments, as inferred from the…
23. 4. 2020 Source: Non-Hodgkin Lymphomas and CLL
konzultace - geriatrický pacient

Efficacy of Combination Therapy for Chronic Lymphocytic Leukemia in Patients with Complex Karyotype

A complex karyotype (presence of ≥ 3 chromosomal abnormalities) is a negative prognostic marker in chronic lymphocytic leukemia (CLL). An analysis of the impact of complex karyotype on the efficacy…
22. 4. 2020 Source: Chronic Lymphocytic Leukemia
konference_kongres_přednáška_potlesk_medicína_lékaři

Role of Chemoimmunotherapy in the Era of Rapid Development of CLL Treatment Strategies and Emergence of New Drugs

In the context of the significant advancements in the field of immunotherapy and evidence of its efficacy in the treatment of chronic lymphocytic leukemia, it is pertinent to ask how this will…
22. 4. 2020 Source: Chronic Lymphocytic Leukemia
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