The first “bites” of the year highlight, right at the start, the benefits of a month of alcohol abstinence. Alongside this, they move from the latest findings on outcomes of proton therapy for oropharyngeal cancer through predictors of dementia all the way to prodromal dreams.

Disruption of transport mechanisms across the blood–brain barrier is considered one of the key factors contributing to β-amyloid accumulation in the brain. A new experimental study shows that modifying the avidity of ligands for the LRP1 receptor can influence its intracellular trafficking and restore transcytosis across the endothelium, opening up new therapeutic possibilities for Alzheimer’s disease.

An international study examined the views of clinical physicians from six countries regarding the acceptability of euthanasia for people living with dementia. The survey revealed substantial disagreement among experts on this topic.

The overuse of antibiotics has helped bacteria become resistant to them. In the fight against antibiotic resistance, the involvement of artificial intelligence in the development of new drugs could prove beneficial. Using AI, experts from MIT examined more than 36 million possible compounds and evaluated their antimicrobial properties. The researchers also analyzed potential new compounds that had not yet been synthesized. The best candidate molecules discovered are structurally distinct from all existing antibiotics and appear to disrupt…

The patient-completed digital BioCog test was developed as a rapid and standardized alternative to paper-based methods for detecting cognitive decline. A study evaluated its accuracy in primary care and its potential to improve the diagnosis of Alzheimer’s disease when combined with a blood biomarker.

V posledních letošních „jednohubkách“ hned na úvod příliš nepotěšíme zapřisáhlé pivaře. Naopak zjednodušení by se díky pokrokům ve výzkumu mohl dočkat management péče o nemocné s karcinomem prsu nebo těžkou depresí. A evergreenem zůstává bezpečnost vakcín...

Multiple sclerosis (MS) remains a daunting adversary for most patients. This disease, which affects the brain, spinal cord, and optic nerve, gradually damages the protective myelin sheath of neurons and, in many patients, leads to chronic neurological impairment. Although modern medications can slow the progression, a causal treatment is still lacking. One of the most promising avenues of the past decade is stem cell research —⁠ an approach considered experimental but opening the door to new, yet unexplored therapeutic possibilities.